A highlight from #385: Insulin Resistance & Diet


My name is leadin here with allen. Flanagan alan how're you today sir. I'm grace i'm good so i'm slowly getting back to normal. What is it day. Aged eight nine now of fair into this study that i'm running at the menace so so far so goods great compliance from participants. Which is wonderful ex. And yeah you're still recruiting people for this study so maybe for people listening because i'm sure there's a significant number who are based in the uk from which you are going to be recruiting from can you. Maybe i maybe mention what the study is but then for anyone who might be interested in becoming a participant. Give them any details there too. Yes so the study is looking at the relationship between meal. Timing and someone's time of day preference so people tend to either have a preference for kind of being what's colloquially known as a morning type or or nitel and there is also a relationship between us your your time of day preference on what's known as social jet lag. Which is maybe the discrepancy between how much you get to sleep when you when you're free to choose your sleep wake cycle versus heme which you actually sleep when you have to get up for work and all this kind of stuff. So we're looking at the relationship between those factors meal timing. it's all observational. So there's no la visits or anything. People completed at home using an where. It's very easy to use you. Take a photograph of the meal that you're eating and it will time stump that meal and the new export it in a pdf and we get the pdf than we can know. That breakfast was at eight thirty six. Am more dinner was at seven forty five and then the apple to add some detail in terms of the composition of the meal. Or what what foods you had so It's going well so far. We are keeping recruitment open until later in the in the full. so if anyone is interested Then yet get until truth me my University email Which i guess you could put in the show notes maybe And yeah just just send me an email and we can. We can take it from there. There's a baseline screening health questionnaire. Which i imagine pretty much every sigma listener will will pass and then we've got some baseline questionnaires. And then we do the two weeks of tracking diet so yes for anyone interested. Get in touch and we would be. We'd be happy to have you onboard. Yeah so contribute to some science and Get in touch if you are based in the uk so at today's topic We're going to tackle insulin resistance. And then we'll also look at the role of diet not only in driving or progressing that forward but also then for someone with established certain assistance. What dietary modifications may be helpful. And so we're gonna try and walk through some of that stuff at this. Of course it area where there is much misinformation or at least very reductionist simplistic advice and often when one. Here's the term instant resistance We've kind of been conditioned to think of. Oh that's a blood sugar plums so therefore forced all about carbohydrates and sugar. And that's and that's a call so hopefully would try and walk through some of this. I suppose from a starting point. We might be yo. It might be worth mentioning why we think of insulin and blood glucose in the same conversation or essentially when there's insistence why is is blood glucose regulation going to be problematic and of course. I think maybe the notable thing to know here is that insulin has many roles as in many ways. It acts to reduce blood glucose so primarily look at it will inhibit blood glucose secretion deliver for example but also has other mechanisms for example increased glucose disposal into a muscle or fat sell all connecting together to lower blood glucose as needed. So if there is a dysfunction there and there is a resistance from cells to the action of insulin. We're going to have problems. Regulating blood glucose. Yeah i think. I think it's thought idea that We do obviously think of glucose and insulin together and we should in many respects but the actual factors that lead to insulin. Resistance are more complex than just the role of blood glucose specifically on of carbohydrate in the diet and uninfluenced quite interesting in terms of our kind of catholic missionary mechanisms. That we've evolved to maintain homeo- stasis in in in different physiological parameters. Blood glucose being one of them that there's a number of mechanisms whether that's a glucose gone or catecholamines like adrenaline or cortisol. That can all raise blood glucose levels and when they go low and the evolutionary speculation here is The danger of hypoglycemia would have been more of a persistent thrash then glossy mia and during periods of evolution scarcity of a nutrient availability and potentially carbohydrate but when we fast forward jt to today's environment that shifts landscape a little bit. And so we have a number of these processes by which we can raise blood glucose levels at. Insulin is the only mechanism by which we lower blood glucose levels and so it

Coming up next