Arthritis, Tony Arnold, Vegas discussed on America Tonight with Kate Delaney


Sitting in our virtual green room is Tony Arnold CEO of set point. I want to ask you question. Did you ever think about this? Do you believe that as zap of electricity? Could relieve arthritis pain that agony that so many people face and listen of all ages recently, I was talking to a PGA tour pro who has arthritis? Can you imagine how many times you have to swing the club? And this is a pretty successful guy. What is he doing? And he searching for the answer. So Tony perfect time to have you on because it does affect is not necessarily someone who's super super older, it affects a lot of people doesn't it. Okay. Room start sometimes as early as eighteen to twenty years old and impacts people. It all ages of light. But when I said the thing about trysofi explain to me what set point is involved with. Sure set point is a working to further Dr Kevin Spacey's discovery that there's an inflammatory reflex. The inflammatory reflex is basically the concept that electrical pulses come from the brain modulator, control inflammation in the body. The body the brain senses. Rent or out of control and slamming, Tori responses in the body by the Vegas nerve. And then since regulatory signals down through that same nerve to control or quiet, and inflammation. So what Dr discovered was it in patients that had excessive inflammation that there signaling mechanism was defective or wasn't effective at regulating inflammation. So he discovered did not putting up a bowl of electricity in the Vegas nerve that you could restore that function or restore the thermostatic controls inflammation in the body and blink people with diseases like room tourists rightous back into a much more normal enroll in relieve their signs and symptoms again with these electrical pulses. Yeah. We're developing the device that actually delivers that therapy and helps treat for the patients a little tiny implantable device. It goes in Vegas nerve in the neck. I'm to deliver those pulses. Wow. And I know this is set point medical is as you say had you're developing that implanted device there have also been with the Vegas nerve. And with Dr Kevin Tracy, obviously, there's the been observing some patients or he's done some trials. And what if they found as far as that's concerned? Yeah. So we've we've done a trial and patients rheumatoid arthritis. It was done across four or five centers in Europe with a really use investigator named Dr Paul Peter tack, and Dr tax greed to meet the primary investigator where we implanted a device up to seventeen patients about half. The patients had never been on one of these biologic Virago, very expensive potent drugs and the other habits sailed biologic drug so kind of both ears. Becker of all the patients had severe rheumatoid arthritis and more coup some degree debilitated, they couldn't button insured or couldn't use a four. They just didn't have a normal lifestyle. A were many of them in their thirties forties. Fifties. What the proposition wise? We would implant these patients with the device I in kind trial, and it never been done before and their disease went as well as all biomarkers, they give an indication of disease. So you look not only at how their joints and. Levels go, but you also measure these specific markers and the blind that are indication objectively forever diseases. Trending so seventeen. Patients were implanted obvious seventeen patients, you know, well over half of the patients. Let's see about eleven of the patient, and very substantial response is a few more modest response isn't a couple got no response at all. In the therapy. But again, a number had remarkable responses were able to resume not only more comfortable life. But a number set I went back within weeks and doing things I hadn't gone years. I'd been on eight different drugs. And none of them were. I was in a really desperate situation and within three or four weeks. I could ride my bike to the Dutch coast. Dr. Ten schools and breast myself and dot the stories that came back for amazing and really happy patients that we're speaking with Tony Arnold CEO of set point medical, Kate Delaney America tonight, the you know, what's interesting about this listening to you. And and I know that obviously we talk about inflammation inflammatory diseases. And there are so many I hear from people who have Crohn's disease Parkinson's. We know Alzheimer's, there's a chance obviously with these trials in the results that you just discuss that this could be something that may be also used in thinking about those other diseases, right? That's absolutely, right. In case. They're they're already been there's another trial with a researcher in France saw our our a trial, and he went to largely duplicate that Kreil and Crohn's disease, which is a very ugly debilitating disease of the system, and he went and applied it there. And I had good success there. We're also conducting fry on that area and early results are positive, and you've mentioned a number of other diseases that did a really ugly, chronic disease. It today. Primarily inflammatory diseases Alzheimer's one and many others that are primarily inflammatory. And we believe this therapy might be a workable for a number of those because he is in a naval people to have. We save for therapy than available drug therapies today at a lower cost for the healthcare system. Yeah. Which wouldn't that be wonderful to see that you have to be as somebody who's in this business? And of course, you're in the business to do. Well, but you have to be excited about what a game changer. This is. Yeah. I've been in this industry. A long time. I've been fortunate enough to develop a bunch of different therapies and Ruth surgery. Near knows this is the most exciting one I've been involved in it. It's the first therapy. I've ever been involved in it. Is a developer of type therapy. If you get really excited because it helps to Beijing. It gives us a Docker another tool to use every Docker may not use it in every case. But it gives him another option for patients his or her patients, and it it cost the provider our healthcare system, far less money. You get any two of those. But you can't have all three together. So we've got a chance here to do something. That's came changing for patients. That's unlike anything that's been done before. And it could actually help health healthcare costs substantially lower. So you just don't see that off. And then the reason you see these this is a paper published recently in the peon AS kademi of scientists. And the reason that such an exciting thing and it received such a high impact of location is again, this has never been done before this whole discovery that you can control what goes on out in the periphery of the body and that joint. Activating nerve in the neck was really a crazy thing Dr free he discovered and people were very skeptical. Now, it's been well established bad at work. And we're just at the tip of the iceberg understanding all things we can do with these type therapy. So we are the first one and we're doing phenomenal thing. But just wait in the next five and fifteen years, we're going to see this new area of medicine a new way to treat patients that hopefully brings a lot of advantages. Oh, yeah. And especially when we started off we talked about rheumatoid arthritis, and how awful that can be for people that simple activities tying the shoe and just getting dressed buttoning your shirt or walking a dog just down the street and around the block just the simplest things. It's not even these ferocious weekend warriors. We're talking about, you know, everyday people that are really suffering with this. Like, I mentioned Tony I've seen so many people and they're in great health. But this is what they're dealing with. And they are so frustrated because there isn't any great treatment for them. So again, the fact that you're on the precipice of changing lives that has to be incredibly rewarding. It absolutely is. And like you said, it's people tend to think of rheumatoid arthritis is strikes people in late in life. It's just not crew affects so many people early in life, and it's not just that you get these pain and suffering the inability to use your joints. And you see the people were hands become disfigured. Also has co morbidity begins to get in the joint little slowly begin to erode the joint and the bond. Tends to have very substantial effects on cardiac system. So almost certainly somebody that has significant RA later in life is a disease progresses. We're going to have many more complications with heart disease and other diseases. We believe if you stop the progress of the disease early therapy like this. You'll also eliminate or reduce any of those complications later in life. So it's not used to being you do here today to make them feel better at something that changes, the course of their whole life when it works. Well, it's really exciting. And as you mentioned the golfer the thing that they're the thing that's available to these patients today is a really potent for some people affective biologic therapy that has to be infused or injected weekly those therapies are very very expensive. And when patients go on they tend not to last a long time. So if people wanted today within a few years after patients will no longer respond to that. European. They're searching for something else for that patient could be on each one of those that they try as its own unique and potentially devastating side effects. So it's.

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