Cheney, Liz Cheney, Wyoming discussed on All Things Considered

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Definitely supporting Liz Cheney. I am a Democrat and am liberal. But I feel like she is just someone who, you know, has strong ethics and has stood up against some terrible things that have happened over the past 5 years. Wyoming Republicans Mark Hanson and Danny remit see things differently. We got a lot of rhinos in there that we need to get out of. Liz Cheney's one. As far as I'm concerned, Liz Cheney's trader. Cheney says she knows what's in front of her. I think that there's no question that I'm the underdog in this race, certainly. Donald Trump won Wyoming with 70% of the vote in 2020, and roughly 69% of the state supported Cheney. But when Cheney started to attack Trump, the state party censured her. Trump then backed Cheyenne attorney Harriet hagerman, and she became the FrontRunner despite Cheney raising three times as much money. It's the most expensive house race in state history. University of Wyoming political scientist Jim king says hagman and Cheney are politically very similar, except on Trump, who Cheney voted to impeach. There is that one vote. And for now, we're participation in the house elect committee. That has obviously rankled some Republicans in Wyoming. Cheney had hoped to talk to more rank and file to explain to them why her time on the committee is important for democracy. She does tell people she still conservative has not changed her views on policy and will fight for the constitution. I've also been clear I'm not going to lie, I'm not going to tell people what they want to hear. But Cheney's time on the January 6th committee has allowed hagman to try and take advantage. Trump spoke in an event for her, and she's traveled the state telling people they need a Wyoming representative. Liz Cheney has not been representing Wyoming for a year and a half. The moment she made the decision to go to war with Donald Trump. That's really the only thing that she has been focusing on. Hagman says she grew up in Wyoming, something Cheney did not, and has spent her entire career as an attorney fighting against the federal government. The state Republican Party has made it clear that hagman is their choice, and she's also been endorsed by many House Republicans. Many of Cheney's donations have come from out of state. Her in state support from many longtime Republican politicians really doesn't have the impact at once did. Cheney says Republican politics is certainly changed. When you look at Wyoming in particular, the chairman of our state party is a member of the OT first. He was on the capital grounds on January 6th. There are photos of him walkie talkie in his hand that day. Then he went home and said that he thought we had a contemplate seceding from the union. Cheney says she would like the party to return to its values, and she plans to work on that, whether or not she gets reelected. Recent polls have her trailing by 20 points and also show that few voters are undecided. But Wyoming does have a significant number of right leaning independence, the Cheney is clearly targeting. The primary is August 16th. For NPR news, I'm bob back in Laramie. Research on Alzheimer's disease is at a crossroads, experimental drugs have been a disappointment so far. So researchers are trying to figure out what comes next. And Pierre John Hamilton has been attending the Alzheimer's association international conference in San Diego this week and he joins us now, hey John. Hey, why are these drugs that researchers were once optimistic about failing? These drugs are going after something called amyloid. It's the thing that forms the sticky plaques that tend to build up in the brains of people who have Alzheimer's. And some of the drugs have proved really good at removing these plaques, but they don't seem to prevent memory loss. So even the one anti amyloid drug that's approved by the FDA that's a drug called add you home, it still hasn't proved that it helps patients. And this morning, I heard details about yet another disappointing result. This was a study of people in Colombia who carry a gene that pretty much guarantees they will develop Alzheimer's at an early age. And they get an anti amyloid drug called chronic for 5 years or more. That's a long time. But it didn't work. The drug might have helped a little, but not enough to achieve statistical significance. There's also been some talk about research into these drugs that appears to be fraudulent. What's going on there? Yeah, so there was an investigative report in the journal science looking at studies involving this researcher from the university of Minnesota. Those studies suggested that one particular form of amyloid causes memory problems in rodents. But now it looks like data from those papers was altered. The report in science says this calls into question the whole idea that amyloid is important in Alzheimer's. But the scientists I've talked to here. They all disagree. You might expect that researchers who do amyloid research would see it that way. So I talked to somebody who is not at the meeting. His name is Carl harrop at the university of Pittsburgh. He's a longtime critic of what's known as the amyloid hypothesis, but he doesn't buy the idea that this one study led the field astray. Here's what he told me. That there was fraud, I think, is very clear that paper in science documents that very, very well. But the evidence in those papers was really tangential to the field. Yeah, so his point is that there are hundreds and hundreds of amyloid studies out there and no single piece of research can have that much influence. Well, if amyloid drugs are not the answer, what is? Well, people are looking at several possibilities that they talked about here. One is drugs that go after these tangles that appear inside of neurons of people with Alzheimer's. There are several drugs being tested that try to get rid of these tangles. Another option is drugs that target inflammation in the brain and other sign of Alzheimer's and today I heard from researchers who presented a study of a drug that helps brain cells metabolize sugar. It acts a bit like a diabetes drug, and there are some signs that this drug can actually slow down memory loss. Well, is there anything that people who might be concerned about developing Alzheimer's can do right now and they're not good drugs on the market to treat or prevent it? Exercise. There are now a whole lot of studies suggesting that people who exercise are less likely to develop Alzheimer's. And today, I heard about a new study that treated exercise as if it were a medicine. It's called the exert study. And it looked at about 400 people. These are sedentary people with mild cognitive impairment, which is the earliest stage of Alzheimer's. And they were all prescribed YMCA memberships and a personal trainer for a year. So typically, people with mild cognitive impairment get worse every year. But in this study, they didn't. And what's really interesting is that the benefit was not only for people who did aerobic exercise, but it also worked for people who just went and did stretching and flexibility exercises on a really regular basis. And PRS John Hamilton

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