Malaria, Autoimmune Disease, Painkillers discussed on Coast to Coast AM with George Noory
Welcome to coast to coast AM. How are you? Great, richard. Thanks for having me. Let's start with a little bit about what bio quark is. And what you do. Absolutely. So, you know, we are a biotech company, and we are developing pharmaceuticals and other healthcare products that are basically taking clues from the natural world to to solve some of the major problems that we have before us and those clues can be from an Vivians as we study how they regenerate or species that do not age or even the ones that, you know, have the skill of dying and coming back to life. We like to take these clues and say, okay, all these other species via the powers of evolution have been here. Hundreds of millions and billions of years before us, how do they survive? So very well. And why do we continually get wiped out by all the diseases? Acute and chronic. That's about as basically biocrops core mission is continuing to look at nature and find these answers that basically been the background the hundred years in the healthcare industry, but we wanna take it a step further. I was reading some of your press material. And I thought this line sort of sums up what we'll be discussing tonight, and that is that bio cork studies. Evolution -arily perfected a raise of meadow bowl lights or small molecules from the natural world that can lead to the development of novel therapeutics for a range of chronic diseases, responsible for human degeneration and suffering which is quite a mouthful, but let's focus on what you mean by the evolutionary perfected arrays of metal bullets. What does that mean? Well, I mean, look out your window. And you know, you might see a tree, you know, the ancestors of that tree were around a billion years ago, they survive I. Ages. They survive, you know, just a nasty stuff on this planet, and they died and get sick of the same stuff to kill. But they don't pay when they get sick ministry outside my window. Here gets sick. It doesn't take, you know, fifty milligrams of amoxicillin it basically create inside itself. Tells shall we say of bioactive substances to defend itself from funguses and bacteria and animals chewing on it and so forth and so one so we say evolutionary perfected over time. These species have had to develop these skills, and whether their plants or bacteria, or you know, and they can regenerate or flat worms that can resist cancer. This is something that happens over time that you know, we as humans. We don't have the skills yet. We've only been here in terms of a couple of million years. So that those are the foods that we're looking for. And when we say metabolite, basically, the natural chemicals and proteins and other substances that these creatures make internally to protect themselves from disease degeneration death. So we'll get into mosquitoes and just a bit. But I want to further understand a little bit more about what you do and what you're hoping to achieve. So when we think of the natural world at the example, I liked I like is the Greenland shark because it was in the news a couple of years ago. And according to a recent study, they the Greenland shark lives at least as long as four hundred years and get this. They reach their sexual maturity at the age of about one hundred and fifty so have we figured out why Greenland sharks, for example, live that long? In is something we we can extract from the Greenland, shark synthesize it into a drug help humans. Let's say live longer healthier lives. Or is that I'm guessing a vast over simplification, not if you've hit it on the head the freemen sharks, a great example of species that are so called negligibly senescence. So basically, they age age extremely slowly in comparison. To us. Another example related to that the Arctic ice landed clam, they found one they've found one recently that was over five hundred years old. It was year before America because here so. Yeah, I mean, these are wonderful examples of how evolution has decided. These species are going to live a lot longer than us. And of course, it's gone via the marvels of chemistry. But, you know, not the marvels of chemistry produce down the road. It's you pod. But reneged, and so yes, besides from you know, some of the other things we're doing and we'll get into negligibly senescence organisms do hold a wide range of bioactive substances that keep them healthy. Whether those are anti-inflammatories antioxidants were wide range of other substances with farm, clouds activity, absolutely beautiful examples in the Greenland, shark is one of the greatest ones. Yeah. And you mentioned flat worms, and I was reading in preparation for this program. I was reading this British newspaper article from twenty twelve and it reported that flat worms could hold the key to immortality. And they could live theoretically forever after they've examined their ability to repeatedly regenerate is that true. Flat. Worms can live, theoretically. Forever. Wurmser probably one of the most elegant example. So they they have a perpetual ability to regenerate through sort of what is sort of a vision process. So every new cell. They create is basically almost embryonic in nature and pristine you can cut the thing apart. They can cut it in half. It regrows you can cut his head off including destroying its brain it regrows in its entirety. And I'm Hal remembers things from before the brain was destroyed, and they have is amazing ability. There's beautiful papers on this to atypically reverse cancer. When you give it to them in the lab. So funny little creatures. You know, you can kill lots of species in the lab, you can kill them by we can kill the rabbit kill the Guinea pigs with tumors, but you give Trump cancer, and it just decides to get rid of it. It turns it into normal tissue and goes happily about it say, so it is one of these lovely examples of biological resilience that the planet has created and yet it can go one wherever in essence as long as it wants to cut very comfortably. And you're right or your press material says nature's eco cream systems represent a completely untapped reservoir. For new drug candidates. Give me a kind of a great six level primer on the actor cream system. Okay. So, you know, many are probably familiar with the endocrine system, which is something that we as humans have which are basically hormone secretions within our body. These are what a lot of these other species do that. In essence bites vomit for lack of better words. Upon us or other species. So think anything that bites you and not only might something from you. But then deposits something within you. And these are most insects do this. We don't think about it. But the mosquito is one beautiful example that deposit. Sales of substances for one purpose or another into our bodies. And I'm not talking about the malaria, zika and that stuff, but these natural secreted substance in their saliva, and it's one of those things that lots of creatures. Do they've been doing it for hundreds of millions of years. I mean, mosquitoes were around biting dinosaurs at some point, and there is a back and forth process. It's not just that they're sucking blood. They're giving things back. And when we say, it's never been explored. We do it's never been explored as to what the purpose of this. Live a whatever you wanna call it it. It's not just bit. There. There's a biologic processes going one year, and a reason something that evolution created that. It's being it's happening. And so that in general is what? Yeah. External secretion that is going to do something to some other creature. Okay. So let's now get to the heart of the matter. And that is as you say mosquitoes spit. Lovely. But how did you have a partner in this venture that you're studying with how did you settle on mosquito spit? I mean, how you sit around in a in a board room brainstorming and he site. Well, let's figure out what we can find in mosquito spit. How did this idea courteous? I it's really very fascinating. Doctor wants me here who is our partner in this project. He spent the last several years university of Colorado working on vaccine option, I specifically in the area of some of these malaria, but also, Dan. Some of the other nasty stuff. Mosquitoes are typically known to carry around and during that production and study back teams he kept running to these problems that. Yeah, you know, they want him to study and create vaccines against malaria. But there was all this other stuff. President in the mosquito saliva, and it was getting in the way of the process. So he basically what what is this other stuff is there? And why is it sounding the hunt for the new vaccine? And so he started basically basically doing what we do. Pharmacology went one. Okay. Let's take this good this bit. And look at it. They either the microscope blasted apart with all the fancy equipment in the lab. And see what's there? And you know, in basically, what was there was this treasure trove of substances that have never been studied before proteins peptides, small molecules. So the obvious question was what do they do? And you know. The antidote. All component of this also fed into it. Because as spoken in the past you never do feel the mosquito bite, you do you see the after effects? Well, why is that? Well, could it be that there's some very interesting painkillers there that we don't know about? And there was one example, another thought the mind, you know, when the mosquito bites you blood never coagulate, if it did the mosquitoes head would explode because you so all of these like basic sort of anecdotal point got to thinking, you know, what there's probably a treasure trove of stuff here. And it's just one of those things that we always think skeet obeyed we're not gonna look any further radio vaccines. But we can't forget that. It's there, and we have to study it. And so that was the basic premise behind why we said, okay, let's go a little further on this. And see what may be there? And how to connect human health. And so if I go into the back garden, and I get bitten. Up and down the back of my calves and so forth. Even though, you know, it's an incredibly annoying. It's itchy and most of the mosquitos up. Here are not carrying. Well. It's it's possible that they can carry I guess Norwalk and different things like that. But. Is am I am I getting any health benefits from that? That mosquitoes spit that circulating in my blood. I even hate saying that. I it's you know, it might sound disgusting. But the truth is, yes, very much very likely when you put aside what I'm just giving maybe carrying in terms of infectious disease. There are tons of substances that when that little look we we we joke around me, call it. Evolutionary perfected flying hypodermic needle. But when it stabs you doing where your blood, it's an essence depositing saliva. Literally, hundreds of substances into you to get into your body and your bloodstream these include as we mentioned painkillers, and it's like, why are you in? But they can also include immunomodulating agents. They could include neuropeptide all of these things modulating for a second. We have sixty five million people in the United States alone. They have some form of autoimmune disease. Whether that's rheumatoid arthritis psoriasis lupus, multiple sclerosis on down the line. And here's set, you know, why do why does the mosquito having immunomodulating substance in why because it wants to modulate your immune system up and down to protect. What was it again you and so once again, here's an example your. We never studied before we haven't epidemic. Here. Let alone around the world in all sorts of autoimmune diseases nowadays. Is there potential connection? And so there's a lovely example, some very positive benefit that you could be getting when you're standing in your backyard. Absolutely. Yes. Should I think twice about, you know, buying those mosquitoes zappers, or or slapping on some mosquito repellent, should I encourage mosquitoes bite me. You know, the issue comes down to clean mosquito. Now, obviously, that's not something that you can buy it began in the wild. So you don't know what mosquitoes carrying what? But in laboratory, we are able to segregate an isolate and extract. That we are interested in studying the message is, you know, if you're not living in malaria endemic part of the world, it's not always be afraid of what of what's happening there because they're potentially a lot of benefit. All right. Listen, we're going to pick this up. We'll pick us up on the other side, and we'll get more on the salivary secretions of hemet affair Amtra pods. I think I said that right? But here is a Bonnie Raitt taking us into the break with an old cover of del. Shannon's nineteen.