Depression, Nucleus Accumbens, Dopamine discussed on Untangle



He's saying numbers of suicide going up, and it's interesting how many people put forth one face to the world and have this other world inside it just that part confuses me so much because like it would be so hard to do. But you have to think from their perspective that the opposite would be harder that what seems to you on the outside to be totally inexplicable behavior makes perfect sense to them, even if they don't like depression, distorts, you were view of your. Ourself distorts your view of your relationships to the point where it's not always in touch with reality or with other people with thanks. So I could from the outside say, oh, why are you depressed? Like, you have so many wonderful people in your life, and you've got so much things going on. But depression, interferes with your ability to experience, the joys from that or to really be connected with it. So for example, depression can make you feel worthless and a burden on the people that you care about into if I care about you can't look you're not a burden. I love you. I care about you on a scorching. But like in your brain, you might be interpreting as oh, well, yes, they love me so much a say that I'm not a burden just because they don't want to make me feel bad. But I know that I am a burden. It distorts you're thinking, it's not always like that. Sometimes it waxes and wanes, but you. You can say to someone so many good things going on your life. You have a good job. You have so much money. But that little spark of enjoyments that most of us have from like L getting paycheck or from doing something fun. That's like a little tickle of dopamine release in the nucleus accumbens that is disrupted in depression such that like the things that should bring you joy or that you used to enjoy no longer have that little spark moments in them. Can you talk a little bit about and you go through this a lot in the first section of your book? But we talk about the regions of the brain that actually impact depression. I really love what you were talking about the ways that the prefrontal cortex inter acts with the make dilemma hippocampus than how our members they're impacted. I found that also interesting, and I love the kind of created this bridge. Non scienc- people understand this. It is really complicated might go was to. Try and simplify it to the point. Where non scientists could understand it. But anytime, you are simplifying it. You're losing some of the complexity, but if you try to communicate something in all of its complexity you end up communicating nothing at all, which is what most scientists abors sound. Like, what are they saying here that I will on this hand, there's this? But on the other hand there's evidence that it in like scientists need to talk to each other in order to like he Munich eight the tiniest little nuances. But I realized that's not most people aren't gonna be able to put that into practice in their lives. The best simplification that I could think of was to think about how depression his problem with how the thinking feeling action circuits in the brain are communicating with and regulating other. And if we wanna get specific about the neuroscience that refers to the prefrontal cortex the limbic system in the stratum that's thinking feeling in action brain respectively. And one of the interesting things is how these all sort of evolved at different stages of our evolution in sort of layered on top of each other than they all amicably interact, but we have this deep habits region of the brain. That's like as old as the dinosaurs that tries to get us to do what's most immediately, enjoyable pleasurable or to just do whatever we've done the most in the past..

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