BTS #28 Jacqueline von Salm PhD on Cannabis Terpenes, Drugs From Nature, Chemical Ecology


Everybody this is Jason Wilson with the curious about cannabis podcast. Thanks so much for tuning in once again today I am really really stoked to be talking to someone who is as interested in ecology and chemistry. Is I am Dr Jack Yvonne Sam. Thanks so much Jacqui for willing to come on the podcast today. Yeah, absolutely, I'm excited. Yeah, totally so to. Briefly introduce you. One reason that your name is kind of floating around in the canvas space. A lot right now is because you were recently Named a recipient of the L. Soley Award for this year. Which is really really exciting? Congratulations for that. Thank you, yeah I. Know Us Pretty Hard just to be part of so on. It was awesome. Yeah, totally. There's like I think five people in total that received that that award. Yeah, I know I had the opportunity to interview justify Shetik. Last year. And now you so now I'm like well. Now gotta find the other three and. At the mall. but that's really exciting. Do you mind explaining a little bit about Y? You received that award, and then we can use that as a jump off point ticket in all sorts of things. Yeah so I was working for a company. Here in Florida called Med their. Move and they had a lot of focus on. Our In D. and the research in really the chemistry aspects of cannabis in trying to develop unique products from there. But in the process when I got hired, since I already had experience in doing a lot of. Detailed chemical analysis of different complex mixtures in different organisms. It just seemed perfect for me to take on sort of the cannabis world and all the different. Genetics and phenotype, some strains, and all the things that are coming out of the industry They all have their own unique chemistry, so we are really interested in figuring out. What the difference was between some of the different strains, and maybe how that might correlate back to the medical side as well. but initially the focus was really just trying to understand the complexity. That was kind of step one, so we wanted to. Try and do our own analysis. I mean every environment can change it. You know even if you mentioned you're interested in ecology, it just chemical ecology is so variable, so we took all of the different turpin cabinets from different strains and compared to each other to show how certain flower might be similar to others, and how it might be different, and in the process a lot of times, the major Turpin that most people really emphasize her talk about didn't really seem to describe a lot of the data or the similarity with. We're really seeing so we dug into trenches of the details and tried to find exactly which may be minor chirpiness or smaller compounds that aren't always focused on. Are, really differentiating different strains, and that's when. We discovered Alpha through gene, which really basic turpin. It's one of the first ones that comes off on the G. which just means that it's really volatile wants to fly away. which also means it's really sensitive to any kind of post processing, and that sort of thing as well so. This turpin was is known for a long time from Frankencense, actually described quite a few different. straight or Species Frankencense that cannabis terminology always comes. Of leading. US Oh different species of Frankencense are actually. Described from Alpha through gene, and even Alpha Beta pining. So that was how I had known it and I'd never really seen. It talked about cannabis much it would. It would pop up occasionally, even Justin Fischetti six. Some of his publications. It was always very minor almost never even. Has Never talked about for sure, it was just kind of included in the table, but no one ever paid attention to it so then when I started to notice that third party testing labs that no one test for it. Really kind of sparked my interest. Even more was okay. We'll maybe something that can help us. Describe. Different strains of different plants is actually not even being paid attention to. So that was what we did, and did you notice? Something that's been on my mind for a long time and Justin and I talked about this too, but. There's an interesting dynamic in the cannabis testing world right now. Where testing labs are essentially you know they. They create their Anna Light. List based on available reference standard mixes basically right, and so that's what drives a lot of that bias. It seems like where there may be these chemical compounds that are present that are being ignored simply because they're not included in these basic mixes that a lot of the labs us. Just a fascinating problem to think about. That I think when I tried to look up a standard for it in any sort of mixture, it was only available in. More essence fragrance or food and those types of. It was never in any cannabis pins, or any sort of generic turpin mixtures. It was only once I started looking more in the culinary perfume moral that I started even find it. So yeah. It's interesting. There definitely were definitely restricted to what's available to us I think that. Obviously the wild variability in flux of the industry in general and politically and everything else is always up to so it. We're only as good as our tests right. And it just goes to show how much we still don't know that we only. There is a good analogy I think Kevin.

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