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Fighting Coronavirus with Dr Bruce Gellin

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Bruce Gallon welcome to fight in corona virus from American innovations. Sivas great to be with you. Thanks thank you. You're you're our inaugural guest here and we couldn't have a better. I won So many questions to ask you but I thought we'd just start with a question that everybody is asking everyone which is like how are you doing right? I mean I'm right now. I'm in a closet in my apartment in Brooklyn not for corn reasons. Just 'cause the acoustics are better than here but where are you and what is your day to day life like right now so thanks so. I'm at my home in Washington. Dc and a lot of us. We do a lot of work at home but also going to have to do some other things. I think that probably spring cleaning will never be the same because these endless listed chores seem to be multiple. Glad you're getting something productive. That's that's great. I want to turn to vaccines. You're at the Sabin Vaccine Institute. What is the state of play? Do you think now. In terms of Cova Nineteen vaccine development. This is a very important question is top of mind and there are a number of approaches being taken a you know. That's that's encouraging that the state of technology is such that if people think they have an idea on approach that they could take. Let's go for it and so there are twenty five or thirty or more ideas. What are called candidate vaccines that are at least being considered some have already started? Clinical trials others are still working away into the system. They may be ideas that people haven't thought of before but I think that's where in past investments in science and biotechnology plus ingenuity at a time of crisis. Like this brings out all kinds of ideas. So I'm encouraged by that as a general principle but at the same time. It's important that these vaccines are evaluated. So that they actually should. They be used perform as expected to to provide the immune response that we think will protect people and are safe enough to give to millions and millions if not billions of people around the world. What the breakthroughs that we need to actually radically accelerate this process. Like is there some scenario in ten years or twenty years where we're able to almost simultaneously develop a vaccine? Is there like a machine learning element to this kind of simulation element to it? Where you could actually simulate a clinical trial with enough computing power or something? I mean it. The ideal scenario would be an emerging viruses shows up and you know ten days later were producing a vaccine in in bulk. Is that ever going to be a possibility? You know. I don't want to never and I getting to that. It's GonNa take some time. I think the first part of that is is to make sure that we have as clear understanding of the human immune system in the human immune response to these to these pathogens as possible because while we can design vaccines that we think are the right thing. It's up to the immune system to actually do the right thing to create immune response. That'd be protective on the vaccine side. We need to have as many different approaches. What are referred to platform technologies ways to make vaccines? People are very familiar with influenza. Vaccines that for a long time until very recently were made only eggs and insert as it were quite well. We we knew how to make it. We knew how they performed. We knew that they create an immunity. We knew they were safe. But we needed to have different systems to create that and the idea of different platform technologies. Because not all vaccines can be developed in these same platforms. Corona viruses aren't gonNA work in an egg system for example and developing as many of these different platforms as possible is GonNa be cake. That's beginning to happen now. I was saying somewhere the other day. The idea of beginning the ramp up to mass production while the clinical trials are happening. So yes you may potentially waste some mass production cycles on a vaccine. That doesn't end up performing as well as we'd hoped but when you do have the one that does perform you're ready to go. You don't have the kind of ramp time. Is that a potential scenario. I think you're exactly right and while there is that a clearly the risk of building something. That isn't the right fit Given what's at stake I think that taking you the technologies that seem most promising and beginning to look hard at what the existing global manufacturing capacity is and when it needs to be and to start to fill those gaps. Is really important

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