Battling Drug-Resistant Fungal Infections
Marco, thanks for joining us. All my pleasure, then a four inviting me. We're GONNA talk about drug resistant Fungal Infections Sign Nexus and your efforts to develop Antifungal to treat these infections. Maybe, we can start with how big a problem resistant. Fungal. Infections. Today. It's a growing problem and simply because Antifungal. A unforgotten being to use many decades ago, and that are very few of them. Only free classes. One, the pollyannas introduce sixty years ago. That's all introduce four years ago, and Makino candidates introduced twenty if ago, and of course, we've all this time. Fungi had an opportunity to develop the fastest against these free classes. This is why we are developing a new class in order to overcome the growing problem of these. Phone. Calls. How threatening are these infections? Well the type section that we're treating. Difficult to treat an invasive fungal infections invasive from getting fashion. Infections meaning infection bloodstream of internal organs. Usually, they happen in patients water immortal compromised. So cancer patients with a undergoing chemotherapy or. Transplanted patients, solid organ transplant, bone marrow, transplant patients, and these patients. They don't have the emotional defense five vs infection. So using fictions. They are very aggressive. They can spread inside the body of the patients in mortality of visiting factions can be still. Now, we've a best treatment between twenty to fifty percent Wayne thirty to fifty percent, go extremely high mortality. You have, infections. Are Not internal like, for example, Mucosal infections of his office of the mouth of China. That, that can be very, very difficult to treat and these are we all the type of infection invasive and dilemma Khoza that we are trying to treat. Now we've our compound. We hear a lot about antibiotic resistance and the causes of that. Why are we having this problem with Resistant Fungal Infections? Very good, question Danny. Video. Not The resistance to antibacterial as being on the wrong line is because bacteria. Very. Quick in developing resistance and reason is because they are very promiscuous. Based chain the. Not Charlie between the same species, but also between different species of bacteria and very for development over resistant to antibacterial usually develops very quickly after a few years of being actual product on the market. I'm fungal. Infections and. July. Up the development is extensive slower. It may take ten fifteen years before the be significant amount of. Become, resistant, and these. These why? Now, we start to see the problem becoming bigger and bigger. When you start to see classes a been introduced point, you're forty years ago or even longer. And reason of the focus romantic materials is because They develop resistance. Very, quickly. And in very visas being before course over the last. Probably fifteen point years. But he's not Antifungal. 's is becoming a major issue and you have new species amounting like a candidate horace of. Be Shown to be more drag resistance with high mortality, very difficult to control infections. Given the.