Alzheimers, Gatica and UC Berkeley discussed on Life of the Law

Life of the Law
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And. Justice. As the court. Opinion. Next turns, the problem of what the judicial rose should be. In light of what we've learned about the role, Facebook, Cambridge, Analytica in twenty six election. What does it mean to have unfounded trust and social media company, and whether now we're having seen type of unfounded trust in either the government or other types of private needs when it comes to bylaws, win formation. This is life of the law. Welcome to in-studio. I'm Nancy Mullane executive producer and were in the studio to talk about our most recent episode Gatica revisited up the borrowed ladder. Joining me in the studios of cake. UD and San Francisco are Assago Bosque professor at the UC Berkeley school of public health and a member of life of the laws. Advisory board, Tony Gannon our senior producer and here in the studio Lee would cow ski policy analyst at the innovative genomics institute at UC Berkeley. So Gatica was released in nineteen. Ninety seven about twenty years ago. It was a SCI fi film, and it was about bioethics in the future. Tony one, would you give us an update? What was Gatica all about Gatica revisited up the borrowed ladder is an episode covering the scope of bioethical dilemmas that we are either in now or very fast approaching. One person asked me about in the title, the borrowed ladder, and I wanted to. To spell that out by way of summary, didn't make the final cut for some reason in the movie, the main character Vincent Anton Freeman whose own genetic code makes him an invalid has to assume or borrow the DNA of someone with better DNA that have Jerome Eugene Morrow. So in the movie, it's very quick line. But people that do this that by or Bara someone's DNA are referred to as borrowed ladders. Also the jeaner it's sort of a derogatory term for people in the universe of Gatica. So the episode came about in conjunction with two screenings of the film one at UC Berkeley, the other at San Francisco public library organized by the center for genetics and society, as well as the Haas institute for fair and inclusive society. You see Berkeley. We made an episode basically about our experience at these two panels producer, Andrea Hendricks, and I went to both these screenings and then sat with the outcomes of these discussions as well as the film for what seem like very long time. But it was it was like three weeks. And then the last thing I'll say is that producing this episode was really fascinating in that the vast majority of the things that we were talking about were just over. My head, but I knew while I was making the, I would need to make decisions about the things that we were talking about in my lifetime about my own genetic code and potentially about my offspring. And right now it seems like with all the opportunities to have your genetics, your own personal genome tested to find out, hey, what percentage of you know Irish? What percentage of whatever am I and what kind of problems does my genetic code carry? It seems like that's a positive thing. You know, it's like everybody wants to have it done. My friend, just her daughter went and had it done, and she's a teenager and I said, wait, do you know any of the consequences of that? So Lee Ann Assadi you study this, what are the problems with getting your genome tested? So this is something actually in a funny way. I had a conversation yesterday. I wanna say it was with my mom about this very topic. We were in a car ride for about three hours. And we're talking about things and she, she said that she was interested in may be getting screened for Alzheimer's, so there's twenty three MEES one of the companies that you can get some information on these kinds of more medical medically, applicable jeans. And I, I kind of pushed around. I was like, really. Why? Why would you wanna do that? I mean, is there something you would do with that information and that kind of led us into this conversation of just what you asked, what are all the the reasons to do it or not to do it? And I think it boils down to, you know, there's there's a few. There's the idea that a lot of these are correlation and not causation, and so there's what core horror Latian so correlation to what to to some kind of outcome. So you have a population of people that have gene mutation in gene, and these are usually mutations. Everybody has the genes, but it's the mutation in the gene that matters and there's a correlation that you can make, and that scientists have made showing that certain mutations poorly meaning the have coincident with a certain outcome medically. So there there are many that we know at a molecular level that we can go beyond correlation. And we can see actually support with causation where we can do experiments and see really what that mutation does at a molecular level. But there are many that we don't and something like Alzheimers very complicated disease, and it's not clear the extent that things are just Corlett of versus causative. So that's one of the big things that comes up is you know, when you're reporting somebody's genome, your reporting on correlations mostly. So if it's not a clear correlation than you could have a sign that you have that mutation, but it doesn't necessarily mean that you have all Alzheimer's, that's right or that you will definitely get or you will get it on the other hand, you know, like I said, there are some that we have really dug in more at the molecular level like sickle cell anemia, where where we know it's much more causative. We know if you have the mutation that you are, you're going to have the disorders will, but there are many that we don't know that. So in other words, you look. Someone's gene there is it called their genome, look at their genome, and you see these mutations and there's not necessarily see others mutation, and that mutation could correlate with Alzheimer's or but wait a minute. If if if you see the mutation and it could correlate with Alzheimer's, but it's not absolutely sure. Well, what do you do with that anyway? Yeah, right. So so usually it's that it does correlate but it could cause. So what's your mom do with that information would ask days, what would you do? And you know, she was like, well, there are some lifestyle changes you can make, and I said, well, yeah, most of those are and she's probably going to listen to this. So I'm sorry, mom, mom recounting our private conversation, but she said, you know, there's, there's lifestyle changes. You can make that reduce your chances. Again, these probabilities reduce your chances of getting Alzheimer's. And I said, well, yeah, those are things like diet and. Exercise and reading and keeping your mind sharp, and and those things correlate with many other diseases and aren't those things you would wanna do anyway. So you know, knowing this, are you really, you know, are you saying that you wouldn't do those in less you knew you were going to get Alzheimer's or the other alternative? And the way that I generally see it for myself and these are personal things. But for me, it's if I knew that I had a very high chance of developing Alzheimer's rather than you know, feeling confident in my ability to take action against that, I would mostly feel scared for the next however, many years. And anytime I forget something I would start to wonder, is that you know what is that? Is that normal or is this the beginning of something? So we talked about that for a while and what that would really mean. And the other thing that came up though that I think is you know, again, from my perspective is probably a really useful to consider is things like estate planning, and he know if. You knew that this was really high likelihood, you could start to do things like prepare for what kind of care you want and what you would want to leave your children. But then you know, on the flip side, those are also things that you'd probably want to do anyway, so so it's it's complicated, but the way you're describing it, it's a positive thing that you could prepare. You could change your diet, you could exercise. I mean, these are all really positive things. If you have an indication that coming down the road, maybe you could delay or alter, you know something that is physically you're carrying that, could you know you could delay the impact, right. But got the movie also introduced that this is a future society

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