Advancing Cell Therapies Beyond Cancer

The Bio Report
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Automatic TRANSCRIPT

Thanks for joining us as a pleasure to be here. We're gonna talk about regulatory t cell therapy and cinema bio therapeutics efforts to develop these for autoimmune and degenerative diseases perhaps we can start their. What are regulatory t cell. Therapy's and how do they work sure So this is a feel that has Really over the last two decades exploded in our understanding of the importance of these cells in controlling everything from allergy to organ transplant rejection to autoimmune diseases. In basically what to rags. Dr is a very small population of white blood cells largely circulating in the blood but also present in tissues and these cells have the capability and capacity to actually shutdown unwanted immune responses perhaps most Typically in patients that have a defect in these cells called apex patients They'll usually die within a year or two of massive autoimmune and allergic responses unless they get a bone marrow transplant from a mother or father that That gives back there to population so these cells are really essential to controlling tolerance in the immune system preventing immune cells from attacking and destroying self tissue. You see these. Potentially addressing large populations of people with autoimmune degenerative diseases potentially how big a market re talking about an. How effective are we today in treating these conditions. Yes certainly this is a very big bucket ranging everything from rheumatoid arthritis to multiple sclerosis type one diabetes and over eighty other autoimmune diseases Up through including degenerative diseases like ls potentially alzheimer's or even parkinson's disease and the reason is is that so many of these diseases are mediated by uncontrolled inflammation. People don't fully appreciate the fact that the immune system is playing an active role in a of of diseases outside of the more classic immune diseases so when you think about market potential it's almost impossible to To ferret out what the actual size will be in reality. of course These cells are gonna be used. I in diseases that are highly morbid and potentially a strong medical need either as disease class or as individuals and we hope to start out in diseases that are clearly a fall within that that rubric but ultimately one can imagine cell. Therapy's being a new pillar of medicine where you can think about them. In a variety of immunological settings where you wanna give a treatment once or a couple of times and then have a long-term living drug that will suppress unwanted inflammatory responses.

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