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Automatic TRANSCRIPT

Today I've got an advanced look at a newly approved weight-loss drug that's GonNa be coming onto the market this year nutrition diva listener. John recently asked me to weigh in on a new. FDA FDA approved weight-loss drug called jealous one hundred. The drug is not yet available to the public. But it'll probably be coming onto the market very soon as as a prescription only drug under the brandname plenty. I bet it's going to be hard to miss it when it does become available because there's probably going to be a huge advertising and marketing push but is this new drug going to be the one that turns the tide against obesity. Previous pharmaceutical approaches to weight loss. Have all had major drawbacks stimulants. Like fantasia mean are quite effective in suppressing appetite for example but they can be habit forming not to mention that Paschi side effective occasionally stopping your heart other drugs such as Orla stat are somewhat effective in blocking the absorption of fat and calories from boots which can be helpful unfortunately they also block the absorption of some fat soluble nutrients not mentioned a rather embarrassing side affect requiring frequent changes of underwear. This new drug takes a different approach that avoids the worst of these side effects. It's it's designed to reduce your food intake by making you feel like you've had more to eat than you actually have so the drug is made from two compounds. That occur naturally in foods foods cellulose and citric acid. You swallow three capsules with a big glass of water before meals and the capsules released particles in your stomach stomach which rapidly absorbed the water and expand to form a harmless GEL. This GEL has no calories but it takes up a fair amount of space in your stomach and your intestines and with less room in your stomach. The idea is you'll eat less and then you'll lose some weight. How well does it work well? In a clinical trial people who used plenty and also followed a reduced Calorie Diet and exercise moderately lost more weight. On average than in those who reduced calories exercised and took a placebo about twenty percent of the people in both groups dropped out before the end of the trial which was scheduled to last about six months months of those who completed the entire six months. The group taking planete lost about six percent of their weight while the group taking a placebo lost is just about four percent so you could say that people taking the drug lost fifty percent more weight than people taking the placebo and that sounds really impressive. However the actual weight loss was pretty modest in both groups? The group taking plenty lost an average of fourteen pounds while the placebo group lost an average average of ten pounds. So we're only talking about an extra four pounds over the course of six months and just as a reminder everybody was also oh reducing calories and exercising now even though the people who were taking planete didn't lose a whole lot more weight than the people who didn't it is certainly possible that they found it a little bit easier to stick to their diets because maybe they didn't feel as hungry. Unfortunately the researchers didn't report on things like perceived hunger or how difficult the subjects founded to stick to their diets they did assess safety and side effects. That's a big part of getting your drug rug approved and there were no big concerns about safety but the group taking the drug definitely did report more side effects than the group who were taking the placebo and most of these side effects were digestive symptoms like diarrhoea or bloating gas constipation or abdominal pain. But most of these were considered mild mild in severity. There are some non-pharmaceutical ways to make your stomach feel fuller researcher. Barbara Roles also has popularized an approach known as volume metrics. And the idea. Here is to choose foods that have a lot of volume but not too many calories primarily merrily these are foods that contain a lot of fluid or a lot of fiber so soups brought whole vegetables and fruits whole grains that sort of thing even just drinking a full glass of plain water before meals has been shown to decrease food intake these volume metric foods triggers special cells in your stomach that register pressure or fullness and this then sends a signal to your brain that you've had enough to eat presumably this feature is designed to prevent us from eating until our stomachs literally explode but because these volume metric foods and liquids. Don't contain a lot of calories. You end up reducing your calorie intake and losing weight. It's basically the same concept as plenty. Only it involves healthy foods instead of