Listen: Bone Building Needs Bit of Breakdown First
"This is science Americans sixty seconds science. I'm Karen Hopkin. Exercise builds muscle, but it also strengthens bones. Exactly how exercise boosts bone strength is a matter of debate and a subject of scientific scrutiny. Now, a new study in mice shows how a hormone secreted by active muscle cells triggers, bone remodeling, physical activity stimulates the release of multiple molecules from skeletal muscle take Iran, for example, this hormone named after the Greek messenger. Goddess iris is produced by running rodents and by us humans when we do high intensity Arabic training once it's generated iris and improves bone density and strength to find out how Bruce Spiegelman and his colleagues at the Dana Farber Cancer Institute and Harvard Medical School took cultured bone cells and located the receptor to which Iran binds, this receptor protein is particularly abundant on cells called osteo sites. These cells of the master regulator of. Bone remodeling and the most abundant cell type in bone. What we found interesting in. This paper is the magnitude of the effects, we get in terms of iris and acting to stimulate osteo sites and preventing their death in culture. Also their ability to make a key protein sclera Sten under the stimulation of iris scores. Ten is a protein that actually stimulates the breakdown of bone that Iran, which builds bone would promote the production of sclera Ston which destroys it may seem counterintuitive but Spielman says that this bit of bone breakdown that signals the body to engage in some skeletal renovation the results appear in the journal cell boning up on the actions of Irishman could help us work out. How we can derive the most from our workouts and possibly keep our bones dense enough to keep us dancing in our dotage. And the new work identifying the receptor. Also allows us to really a much more easily identify. What are other target cell types for IRA Sinn with particular reference to neural cell types, where there is suggestive evidence by us and others that iris in may play a neuro protective effect in disorders, such as Alzheimer's disease, Parkinson's disease and a LS? Thanks for listening for scientific Americans, sixty seconds science. I'm Karen Hopkin."