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Automatic TRANSCRIPT

So some really interesting things to talk about today. And as I mentioned we're GonNa talk about relation. And why don't we just start with with some bedrock information for Are Lay people and practitioners about you know what is methylation uh-huh and if you could just give us a basic overview of it is and how it works Yasser. Listen if you've got any serious sort of folk history geeks It was actually we just the body it was just we were D- Our ability to mesylate compounds To detoxify them was first discovered in eighteen. Eighty seven if anybody needs a cocktail party factoid. But it was it was long after that before the methylation methylation cycle was actually characterized SEM SEO. Methionine was discovered. You know it was in the twentieth century. When when all of that was teased out so methylation is really quite simply as you know either were putting a a a methyl group with his car which is carbon three hydrogens either were? We're I by adding it to a compound or we we are. We're removing it from a compound or we are producing ESA Dennis on a seal methionine. which is the cofactor that carries that methyl group that can be put on compounds? So that's fun. That's what methylation is and it's everywhere you know it's it's in Internet Lord says Those those those folks talking a lot about methylation say it's happening in every cell all of the time crime and I would argue that. It's probably pretty close to that. I mean it's interesting to me that we use this addition of a methyl group Rupe or The methylation cycle which interfaces as you know intimately with the full late vitamer cycle insult curation. But you know it's interesting that we use these. He's in such important fundamental Processes you know body wide just to give you a couple of ideas nick of its importance. Three of the four DNA bases require a functioning fully slash methylation cycle for production three of the four basis and that fourth base which has cited scene is the base that Indiana methylation gets methylated. So Oh for D for for gene expression fundamentally for gene expression. We have to have good math elation and for DNA repair. We need good mcmath elation so just think about it to make DNA to regulate DNA expression to repair DNA all requires really you know high functioning math elation and sue just as I've been into this more and more and more right from an evolutionary perspective I I just ponder How interesting it is that we just we use it everywhere so and then additionally a lot of the folks interested in methylation know for instance that we're detoxifying hormones toxins oxen's Histamine Clarence neurotransmitter synthesis phospholipids at the US? Like you know choline is a really methyl donor a demanding process. We use it to to Make creating you know in in in Muscle Energy In you know in kind of on and on a stem cell. So here's another really interesting thing going. Back to the EPA genetic regulation. The regulation of DNA expression are stem. Cell fate is determined by our DNA methylation patterns so Camino Genesis Genesis and Embryo Genesis High methylation activity times very much. So so are you going to be a brain cell or a lung cell or a Gut Sell Etcetera Etcetera Sarah. Although stem those pluripotent stem cell roles are defined through DNA methylation patterns And prior to that you know the DNA methylation Asian patterns from Mom and dad you know in the sperm and egg those are mostly wiped clean and the new patterns are laid down. They're not completely wiped I to clean and so the Herod Ability of DNA methylation is actually established in this really early time and I know you're paying attention in this Serena how much you're focusing but I know that you're a really smart guy with a broad area of interest. So you know. The the the heritable the EPA genetic Connecticut ability is Is In this arena. The fact that we don't completely erase all of the DNA methylation patterns from mom and dad or grandma. AM ON GRANDPA and generations prior and they're carried forward so it's just it's extraordinary. This whole areas has become quite interesting. Today I'm going to stop for a minute. I mean so with with so many connections to to methylation since it's kind of at the the core of of what's going on the sell. It has to be difficult at times to figure out if it is truly connected to the patient's condition and good question. How how do you approach was the need or you know the the interest in looking deeper into methylated in particular patients? Are there any particular conditions not sendo. Well that's a really good question arguably we all need to be addressing methylation Dan and arguably we wanna be doing it really upstream. So there's you know there are certain times we're GONNA be leaning more heavily like you know pre preconception. Planning you know when you know women who are pregnant we we want to be leaning on it more heavily I know there are host of conditions nations that you know some of us in in in our arena have associated with elation defects more. Obviously it probably the best evidence is around depression and You know other neuropsychiatric conditions certainly in autism we we we comments commonly method methylation defects. So I ah but I want to. I guess I want to say that my my so a big practice exchanger for me has been thinking much more upstream and globally about methylation in really putting a lot of attention on EPA genetic methylation and I want to give you a little bit of the backstory neck. Interrupt me if I'm going on too long but let me just talk about that and that I think this will kind of elucidate where I'm coming from. So you know back in the lab you know years ago we were looking at methylation all the time looking at amino acids associated with the methylation cycle. Of course we always look at home assisting at Sarah we're looking at self Eurasian and so we've been thinking about it for a long time and then we started to layer and single nucleotides polymorphisms and you know in the hopes that we would get sort of a more for a deeper more useful clinical picture arguably. I don't know we we didn't. I don't know that that that. Mta chaffar status always always lens much clarity to a patient's condition. I don't know that it you know I I would say it's actually the exception that it really game changes how we approach patients nations So we had the organic acids and the various biomarkers there. We layered in the single nuclear type polymorphism and you know maybe a little benefit not that much. So I flash forward EPA GENETIC RESEARCH STARTS really really pouring out over maybe the last eight eight years or so. I mean extraordinarily so and for me in about twenty twelve twenty thirteen enough studies on epigenetics and cancer. Were moving across my desk that I realized I needed to dive in like I needed to start to understand. Stay on this and a deeper way. Honestly you know it was yet another. Oh Mix investigation and I had a little bit of comics fatiguing at that time and I was like Aw You know here's just another really complicated kind of Arcane physiologic processes going on that. I need to understand dammit but there I did dive. And and the bulk of the research is in the epigenetics cancer and by-in-large you know the most important genetic mark appears here's to be DNA methylation as I unpacked it. It became a practice game changer for me. So the background in it is that in cancer. So the tumor number micro environment is very effective. At harnessing our own EPI genetic machinery intake taking Over DNA methylation for its own nefarious ends. So when we hyper mentally a promoter region of a gene that gene is effectively turned off when we hypo methylated when we win those when either there is an absence method groups on The the gene need or those methyl groups are removed. That gene is allowed to express so the tumor micro environment can very efficiently hyper methylated tumor suppressor genes and so the first question for me as a as a functional medicine doctor looking at methylation prescribing vitamins. HIGH-DOSE B twelve full eight. All of the time and was well. Geez you know. Do I need to stop doing that. In my patients who I'm suspecting cancer in or who are in an age range of an increased risk or who have cancer etc these. These stopped me in my tracks. These papers that were pouring out hyper methylated and you know could could who'd supporting or pushing methylation for a word have some kind of an impact and it turns out. There's an a suggestion in the literature that perhaps perhaps it could now has that stopped me from prescribing vitamins. When my patients need them no not at all but I began to wonder about it an upstream approach to math elation? There's nothing in the literature so wit. Let me actually back up and say HYPO. methylation of the DNA so global global Haifa methylation of all the DNA is something that happens as we age all of us are moving towards less global methylation but then there are these regions of hyper methylation where we don't want them it's like are it's like our DNA methylation becomes disordered as a part of the aging process and you can see that it it underscores all these complex chronic diseases including auto immunity. You had mentioned that your audience tends to be interested in that you seeing these disordered patterns happening putting in all these diseases of old age So globally it's an it's low methylation but these pockets of imbalance hyper methylation good genes being shut down like nerf to tumor suppressor genes and on and on so so my first question was you know. Can we effectively move upstream upstream and prescribe a a methyl donor rich Diet and looking in the literature as you know there's there are no studies on Greens on Leafy Greens cancer. So we know these are safe. You know beats beat rich Diet and cancer really not out there even liver which is a methyl donor superfood you. You know. There's no sociation unless maybe eight really really lousy liver With causing cancer so we saw that we could actually push athlete with a diet and beyond safe if grounds