Malaria, Painkillers, Partner discussed on Coast to Coast AM with George Noory
Deals, and bringing lead drug candidate from discovery stage to phase three development prior to that he was employed by SmithKline Beecham, pharmaceuticals working in sales, marketing and business strategy positions. Ira has also served as vice president of corporate development for the pharmacy benefit management company, prescription delivery systems. He has an MBA from temple university and a Bs in pharmacy. From Rutgers University IRA s pastor welcome to coast to coast AM. How are you? Great, richard. Thanks for having me. Let's start with a little bit about what bio quark is. And what you do. Absolutely. So, you know, we are a biotech company, and we are developing pharmaceuticals and other healthcare products that are basically taking clues from the natural world to to solve some of the major problems that we have before us and those clues can be from an Vivians as we study how they regenerate or species that do not age or even the ones that have the skill of dying. And coming back the way we like to take these clues and say, okay, all these other species via the powers of evolution have been here. Hundreds of millions and billions of years before us, how do they survive? So very well. And why do we continually get wiped out by all these diseases? Acute and chronic. That's basically biocrops core mission continuing to look at nature and find these answers that you know, basically been the background for the last hundred years in the healthcare industry, but we want to take it step further. I I was reading some of your press material. And I thought this line sort of sums up what will be discussing tonight, and that is that bio cork studies. Evolution airily perfected, a raise of metal bullets or small molecules from the natural world that can lead to the development of novel therapeutics for a range of chronic diseases, responsible for human degeneration and suffering, which is quite a mouthful, but let's focus on what you mean. By the evolutionary perfected arrays of meadow lights. What does that mean? Well, I mean, look out your window. And you know, you might see a tree, you know, the ancestors of that three were around a billion years ago, they survive, I is they survive, you know, all sorts of nasty stuff on this planet, and they died and get sick of the same stuff to kill up. But they don't take when they get sick ministry outside my window year. Get sick. It doesn't take, you know, fifty milligrams of amoxicillin it basically creates inside itself. Hotels, shall we say of bioactive substances to defend itself from funguses and bacteria and animals chewing on it and so forth and so one so we say evolutionary perfected over time. These species have had to develop these skills, and whether their plants or bacteria, or, you know, incipient victim regenerate or flat worms that can resist cancer. This is something that happens over time that you know, we as humans. We don't have these skills yet. We we've only been here in terms of a couple of million years. So that those are the clues that we're looking for. And when we say metabolite, faithfully the natural chemicals and proteins and other substances that these creatures make internally to protect themselves from disease degeneration and death. So we'll get into mosquitoes and just a bit. But I want to further understand a little bit more about what you do and what you're hoping to achieve. So when we think of the natural world at the example, I liked I like is the Greenland shark because it was in the news a couple of years ago. And according to a recent study, they the Greenland shark lives at least as long as four hundred years and get this. They reach their sexual maturity at the age of about one hundred fifty so have we figured out why Greenland sharks, for example, live that long and his your something we we can extract from the Greenland, shark synthesize it into a drug help humans. Let's say live longer healthier lives. Or is that I'm guessing a vast over simplification. No, if you hit it on the head Freeman sharks, a great example of species that are so called negatively senescence. So basically they age, but they age extremely slowly in comparison to us. Another example related to that the Arctic ice Iceland clam. They found one they've found one recently that was over five hundred years old. It was year before America northbound 'cause here so yeah, I mean, these are wonderful Zambales of how evolution has decided. These species are gonna live a lot longer than us. And of course, it's done via the marvels of chemistry, but not the marvels of chemistry produce down the road. It's you pod. But reneged, and so yes, besides from you know, some of the things we're doing and we'll get into negligibly senescence organisms do hold a wide range of bioactive substances that keep them healthy. Whether those are anti inflammatories or antioxidants were wide range of other substances with pharmacological activity, absolutely beautiful examples in the Greenland, shark is one of the greatest ones. Yeah. And you mentioned flat worms, and I was reading in in preparation for this program. I was reading this British newspaper article from two thousand twelve and it reported that flat worms could hold the key to immortality. And they could live theoretically forever after they've examined their ability to repeatedly regenerate is that true. Flat. Worms can live, theoretically. Forever. Wurmser probably one of the most elegant example. So they they have a perpetual ability to regenerate through sort of what is sort of a vision process. So every new cell. They create is basically almost embryonic in nature and pristine you can cut the thing apart. They can cut it in half. It regrows you can cut his head off including destroying its brain it regrows in its entirety and to somehow remembers things from before the brain was destroyed, and they have is amazing ability. There's beautiful papers on this to basically reverse cancer. When you give it to them in the lab. Funny little creatures. You know, you can kill lots of species in the lab, you can kill them by you can kill the rabbit, and you can kill the Guinea pigs tumors, but you give room cancer, and it just decides to get rid of it turns it into normal tissue goes happily about it say, so it is one of these lovely examples of biological assay resilience that this planet has created. And yet it can go wherever in essence as long as it wants to cut very comfortably. And you're right or your press materials says nature's ExCo cream systems represent a completely untapped reservoir. For new drug candidates, give me a kind of a great six level primer on the screen system. Okay. So, you know, many in the are probably familiar with the endocrine system, which is something that we humans have which are basically hormone secretions within our body. Oh, what a lot of these other species do that in essence bites spit vomit for lack of better words upon us or other species. So think anything that bites you and not only my something from you. But then deposit something within Yale, and these are most insects do this. We don't think about it. But mosquito is one beautiful example that deposit. Sales of substances for one purpose or another into our bodies. And I'm not talking about the malaria Zeke and that stuff, but these natural secreted substances in their saliva, and it's one of those things that lots of creatures. Do they've been doing it for hundreds of millions of years. I mean, mosquitoes were around biting dinosaurs at some point, and there is a back and forth process. It's not just that they're sucking blood. They're giving things back. And when we say, it's never been explored. We it's never been explored as to what the purpose of this. Alive. Whatever you wanna call it. But it's not just sitting there. There's a biologic processes going one year and reason something that evolution created that. It's being it's happening. And so that in general is what? Yakin system is external secretion that is going to do something to some other creature. Okay. So let's now get to the heart of the matter. And that is as you say mosquitoes spit. Lovely. But how did you and you have a partner in this venture that you're studying with how did you settle on mosquito bit? I mean, how you sit around in a in a board room brainstorming. And he said, well, let's figure out what we can find in mosquito spit. How did this idea courtesy you? It's really very fast. And the doctor wants me here who is our partner in this project. He spent the last several years university of Colorado working on vaccines production. I specifically in the area of some of these malaria, but also Dan gays other nasty stuff mosquitoes are typically known to carry around and during that production and study genes he kept running to these problems that. Yeah, you know, they want him to study and create vaccines against malaria. But there was all this other stuff. President in the mosquito saliva, and it was getting in the way of the process. So he basically, you know, what what is this other stuff is there? And why is it can standing the hunt for the new vaccine? And so he started basically, basically doing what we do sort of basic pharmacology went to one, okay? Let's take this good this bit. And look at it. They microscope blasted apart with all the fancy in the lab and see what's there? And you know, in basically, what was there was this treasure trove of substances that have never been studied before proteins peptides, small molecules. So the obvious question was what do they do? And you know, the antidote all component of this also fed into it. Because you know, as spoken in the past know, you never do feel the mosquito bite you do you see the aftereffects? Well, why is that? Well, could it be that there's some very interesting painkillers there that we don't know about? And there was one example, another thought seems to mind, you know, when the mosquito bites you blood never coagulate, it did the mosquitoes head would expire explode because it just stuff it out. You. So all of these like, basic sort of anecdotal point got us thinking, you know, what there's probably a treasure trove of stuff here. And it's just one of those things that we always think skeet obeyed we're not gonna look any further. Event. But we can't forget that. It's there, and we have to study it. And so that was the basic premise behind why we said, okay, let's go a little further on this and see what may be there. And how it connect human health. And so if I go into the back garden, and I get bitten. You know up and down the back of my calves and so forth. Even though, you know, it's an incredibly annoying, and it's itchy and most of the mosquitos up. Here are not carrying well. It's possible that they can carry I guess Norwalk or different things like that. But. Is am I am I getting any health benefits from that? That mosquitoes spit that circulating in my blood. I even hate saying that. It it it it might sound disgusting. But the truth is, yes, very much very likely when you put aside what I'm just giving maybe carrying in terms of infectious disease. There are tons of substances that when that little look we we joke around be call it. Evolutionary perfected flying hypodermic needle. But when it stabbed you it's doing nothing your blood. It's an essence depositing saliva. Literally, hundreds of substances into you to get into your body and your bloodstream these include as we mentioned painkillers, and it's like, why are you in? But they can also include immunomodulating agents, they could include neuropeptide all of these things modulating for a second. We have sixty five million people in the United States alone that have some form of autoimmune disease. Whether that's rheumatoid arthritis psoriasis lupus, multiple sclerosis on down the line. And here's why do why does the mosquito having immunomodulating substance in it why because it wants to modulate your immune system up and down to protect what does it again you? And so once again, here's an example, we never studied before we haven't epidemic here. Let alone around the world and also. Sorts of autoimmune diseases nowadays is there potential connection. And so there's a lovely example of some very positive benefit that you could be getting when you're standing in your backyard. Absolutely. Yes. I think twice about, you know, buying those mosquito zappers, or or slapping on some mosquito repellent. Should I encourage mosquitoes to bite me? The issue comes down to clean mosquitoes. No, obviously, that's not something that you can buy it began in the wild. So you don't know what mosquitoes carrying what? But in laboratory, we are able to segregate and isolate and extract. Substances that we are interested in studying. The message is if you're not living in malaria endemic part of the world. It's not always be afraid of what of what's happening there because there are potentially a lot of benefit. All right. Listen, we're going to pick this up pick us up. On the other side, and we'll get more on the salivary secretions of hemet affair. Anthropoids? I think I said that right? But here is a Bonnie Raitt taking us into the break with an old cover of del. Shannon's nineteen sixty one classic.