Alzheimer's Disease, Atherosclerosis, Cardiovascular Disease discussed on Talking Biotech Podcast


It's a huge amount. And so it seems like a really intuitive target. Yeah, and what's the biggest genetic risk factor for Alzheimer's disease? It's the APOE gene, right? And the APOE gene is a cholesterol transporter, and people, it hasn't gotten nearly enough research, and it's still not well understood, is why is your particular elite of APOE, the most predictive, it's not an allele of something that creates Sam line beta or something related to tau. It's an allele of cholesterol metabolism, and it's not well studied or understood enough yet, but clearly, in my mind, cholesterol should be involved in the disease. So what's next for underdog? Aside from these drugs which are targeting the oxidized cholesterol, what else is in the on the whiteboard or potentially in the pipeline? Yeah, so first and foremost, we're trying to get our first drug approved for an aspect of cardiovascular disease caused by atherosclerosis. Secondly, we want to see if there's other indications of their diseases that will benefit from our lead drug. But third, we have this platform for designing cyclodextrins to bind small hydrophobic junk, biomolecules that accumulate with age. So there's other oxysterols that result from free radical damage that we can target. Other things that build up in the lysosome, other aspects of that may be good targets. There's other things in the eye. Not only does oxidize cholesterol build up in the eye and contribute to macular degeneration, but so do retinol derivatives like biz retinoids that are the result of damaged retinol, which also happens to be small and hydrophobic, and something that we might be able to target with our technology. So those are some examples of things that we want to go over and go after with our technology. So where can people learn more about aging biology and longevity technologies? Yeah, so more broadly you can listen to podcasts like this to podcasts that are focused on aging itself. You can go to websites of organizations like the life extension advocacy foundation, their social media is fantastic and their messaging on aging and damage repair is great. The Sens research foundation, which is where our technology spun out of is a good source, the buck institute on aging has a lot of great resources. I almost shouldn't be picking winners here because there's so many that I'm going to leave out so much. But there's also some great books that people could read. I think books, the most curated and densest way to learn, if you're not, you know, a scientist reading the primary literature and you want to absorb an entire field in one or a few books, I'd recommend ending aging and ageless by Andrew Steele a second to the first by Aubrey de grey. Okay, that's really helpful. And maybe along that same line..

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