Scurvy, Guinea, Axel Holst discussed on This Podcast Will Kill You

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But it just speaks to the fact that there was still active debate on the cause and thus the treatment of scurvy viewing disease as a deficiency rather than as a positive state was a really difficult thing for people to conceptualize, especially when everyone was looking for the thing, pathogen toxin, whatever that actively caused disease. It was way pastime for some real experiments to begin. Fortunately in the nineteen hundreds experimental studies of scurvy, became popular and more importantly possible. Thanks to a very lucky choice of animal model. Oh my God. I was just going to say how could they have done? Did. They just happen to choose Guinea pigs. Yeah. Are you serious? Okay. Okay. So there's a reason behind this is I I am amazed right now because our animals a freaking Guinea pig. You choose home. I gosh. I don't remember. If we've talked about what animal models are before in this podcast. I don't know we've kind of mentioned them, but we haven't explained them necessarily. Yeah. Yeah. I mean, basically in medical research, if you're trying to learn more about human disease or treatment for a disease. You can't really do a lot of experimental research on humans directly. So it's really important to have an animal in which the disease act similar to the way. It doesn't. Humans. Yeah. Anyway, the issue of an appropriate animal model for scurvy had come up before. Because as I mentioned some animals can synthesize their own vitamin C. So rats had been a popular lab animal at this time lab rats and pigeons, actually, but lab rats were viewed as like in infection carrying and gross like the tide had turned against rats around this time, and they were really gross. But Guinea pigs have started to be imported as pets for children and his little just cute things. And so possibly lab animals. Oh, my God says some guy named axel Holst somewhat randomly chose a Guinea pig as a model for scurvy, and it just happened to work the amount of coincidence in science and scientific discoveries is finan. Comino? Yeah. So now the experiments could begin and they would show that scurvy was directly related to diet and fresh fruits vegetables, raw milk, some kinds of meat prevented scurvy. The are so many important names that contributed to this research, but I wanna quickly shout out Dr Harriet chick who's lab in London consisted almost exclusively a women because all men were at army labs during World War One. I love it and her research show that the amount of raw milk fed to a Guinea pig determined whether or not the animal would get scurvy. Wow. Harry yet harriett. So they knew what scurvy. So they knew that scurvy was related to diet. But what was the unifying thing in all of these anti scrupulous foods, vitamin C, which at that point was still unknown. Yeah. It was just called vitamin C because vitamin A and B. I had already been found as attritional factors which that were necessary for the growth of rats, wait survey just found these compounds. And they just were like, okay, we'll how this vitamin A, and we'll call this when vitamin B N. So with this when they were trying to figure out scurvy. They were just like, we know it's something different. So we're going to call it vitamin C. But we have no idea what it is. I was just a numbering system and naming system for things they don't know. Yeah. That's amazing. I think a and b might have been known. I'm not sure about. Yeah. See was not that is so whole Larrea. Yeah. In nineteen thirty a Hungarian chemist named Albert sent Georgi isolated a compound, which was later name. A scorebig acid also anti score Buick scorebig. You just blew my what's up..

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