Davila University Of Medicine And Pharmacy, Empty Anderson, Dr Matthew discussed on Cardionerds



Carol. Davila university of medicine and pharmacy in her home country of romania after medical school. She finished two years a cardiology residency. Bucharest followed by a research fellowship. In interventional cardio oncology at empty anderson texas. She's a cards fellow in housing. We are very very excited to have her here with us today. Welcome te'o hello everybody and thank you for the kind introduction. I have the privilege of introducing. Dr matthew booed off professor of medicine at the david geffen school of medicine at ucla. And the endowed chair of preventive cardiology at harbor. Ucla medical center. Dr boobs research focus is devoted to cardiac prevention early coronary. Atherosclerosis detection and determining the effect of therapeutic options to stabilize and reverse coronary atherosclerosis. He was awarded the albert nelson marquee lifetime achievement award and twenty eighteen and was named to the world's most influential scientific researchers in two thousand eighteen and in two thousand ninety. We are thrilled to learn from dr booed off today. Welcome to cardio nurse sexual booed off all. It's a pleasure to be here. Thank you so much for having me on dr put off. It's a real real pleasure. We've been looking forward to having you for quite some time and thank you so much for taking time to join us today. We definitely want to kick this off by. Ask you the question. We have many of our faculty guests of join the series. How did you get interested in cardiovascular prevention. Well you know. It went back to when. I was introduced. Chuck schumer coronary calcium standing as an intern in internal medicine. I i was working with the chief of cardiology at the time and he told me that he had this. Mammogram of the heart. That we're gonna be using practice to fight early heart disease and getting people on the road to better treatments and better behavior long before their first heart attack or stroke or cv death and a really got me started down this road in you know as they say. The rest is history. I've been fortunate to be in the right place. At the right time and really be at the forefront of some of these imaging modalities that have now become more commonplace. That sounds very exciting. So you know. Let's start by talking about the structure and metabolism triglycerides. I know by chemistry can be a bit challenging. But you know. Let's try to tackle this subject together. I'll just go through a few basics. Triglycerides are hydrophobic substances which are packed into the core of leipold protein. Leipold will proteins are covered by lipids and proteins set can travel freely through the extra sailor environments inside the body and these. I'll call together apple apple proteins. The main way to transfer dietary than dodge and his triglycerides to tissues is through two types of triglycerides rich leipold protein secreted by intestine and deliver kylo microns and very low density lipoprotein or via ldl and order to unpack these triglycerides. Rich life will proteins. The body produces life a protein light base which releases free fatty acids and remnant leipold proteins. I don't know if you're also following me. I know this is all complicated. But basically triglycerides can be endogenous produced by the liver or exogenous from diet absorbed by the intestine in order for these to be transported through the throughout the body. They're covered by apple apple proteins giving rise to field yell from the liver and kylo microns from the intestine. Once they reach the tissues there again. Broken down into so-called product of interest. Which is the free fatty acid in a byproduct which is remnant leipold proteins. The main places in the body were this process occurs the adipose tissue where free fatty acids are used for storage and the muscle tissue both the skeletal muscle and the cardiac muscle us. Free fatty acids as an energy source for muscle. Contraction remnant column icons envy. Ldl are then mostly taken up by the liver using ldl receptors. And they're then used to produce vod ldl or ldl again so recycled. But some of the remnant hype..

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