Penicillin, Albert Alexander, Oxford Penicillin discussed on Stuff To Blow Your Mind
It's kind of getting stuff wet with this this stuff that that that fights bacterial growth, but they couldn't isolate the compound that was causing the. The effect and stabilize it and make it make it generally useful so to quote from Aminov. Paper Aminov that I mentioned earlier quote for twelve years after his initial observation Alexander Fleming was trying to get chemists interested in resolving persisting problems with the purification and stability of the active substance and supplied the penicillin strain to anyone requesting it, but he really he, he could never cracked the nut oatmeal and he didn't finally make this discovery of the process I for stabilizing and isolating the compound and by nineteen forty. Aminov writes that fly. Ming finally abandoned his quest wood. Fortunately, it was right about that. That time that capable team at Oxford University, including the researchers Howard flurry in Ernst chain or Chine. They picked up on this research and they. They kicked off the research project that would eventually break through on this and they're all these interesting story, so of course, this is while World War Two is going on right so research conditions are not ideal, and there are all these stories about how they turned their lab, at Oxford into this giant incubation center, or factory for mold, like they employed all these lab assistants who were these women who had been referred to in some sources as the penicillin girls. And they would work too like they would work to grow the penicillin and buckets and tubs, and basically every container that they could And eventually they did. They were able to isolate and stabilize this compound so to quote from an Article from the American Chemical Society. In nineteen forty Flory, it'd be Howard Florey carried out vital experiments, showing that penicillin could protect mice against infection from deadly STREPTOCOCCI then on February. Twelfth Nineteen, forty, one, a forty three year, old policeman Albert Alexander became the first recipient of the Oxford Penicillin he'd scratched the side of his mouth while pruning roses, and developed a life threatening infection with huge abscesses affecting. Affecting his is facing lungs, penicillin was injected and within days he made a remarkable recovery while, but unfortunately despite this recovery, which lasted for a few days they ran out of the drug and Alexander, eventually got worse again, and he died and I was reading that they were so desperate to cure him that after Alexander urinated while on his antibiotic course, they would. Would collect the urine and try to extract the penicillin. He excreted again so that it could be re administered to him. and I should mention also that the the process that the Oxford team relied on to extract and purify the penicillin. The mold juice was led by another important biochemist, a guy named Norman Heatley but this case of Albert Alexander shows. Shows an obvious early problem they had which was the problem of scale. They simply lacked the ability to make penicillin scale it that would be needed to even one person. Let alone. The whole world the strain of mold that they were using didn't make enough of it, and this led to the search for other species of the same fungal genus concilium. concilium, which would maybe they thought produce higher concentrations of the Penicillin Phil Trait, and I was reading an interesting article by the University of Michigan Physician and medical historian Howard Markel. That tells a really interesting story I'd never heard about this The so the story goes like this..