Leukemia discussed on Nature Podcast

Nature Podcast
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Automatic TRANSCRIPT

Perspective if you have a patient as lukaemia if you treat them with chemotherapy that raises the leukemia but it also raises their immune system and so it's very helpful to give back blood stem cells from a matched donor like a brother or sister and they end up amplifying tremendously to reconstitute the blood system so i can see what you're interested in studying these blood stem cells and this paper rather than looking at leukemia treatments or anything like that is actually the evolutionary perspective it's quite interesting when we first started studying blood development in my lab i knew about being a hematologist i knew that the blood cells are formed in the bones but when we started doing work and the other model organism that i studied the zebra fish we found that the kidney was where the blood cells were made and the blood stem cells were actually in the kidney and it was kind of strange to me to think that why isn't in it in the same place and so that's been the central question of this paper and the evolutionary implications of that and people are nine for a while that blood stem cells live in different places into creatures so fishes in the kidneys fabian of in the liver birds in mammals it's in the bones but it wasn't really clear why that would be the case but you went even trying to answer that question when he started out you initially studying the environments around the the blood stem cells in your body so what other cells and things was rounding them this sort of niche that right that's right so in these organs that have stem cells there are specific regions that are very important to support those themselves or to nurse those stem cells and these regions are known as the stem cell niche.

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