Dna Damage, Fatty Liver, Nasd discussed on Ben Greenfield Fitness
Referral nerve function. So you can feel things and see and hear things. But in addition, metabolism includes a repairing damage. So there is DNA metabolism that involves, you know, sensing DNA damage and repairing it. There's the ability to convert one set of molecules to another so we can take those, you know, bulk foods and our adrenal glands can turn those into sex hormone. So we we make our own Andrew Jans. We make our own estrogens men and women make Andrew Johns and women for the most part, make estrogens and that's the type of metabolism and essentially any type of metabolic process that you can think of, including building up your muscles and restoring your Russell function after workout involves metabolism and NASD's. The central. Regulator NA D. And then three other related compounds that are called any h and ADP an ADP. Those are the central regulators of metabolism. Now, the thing about any d. is you think, okay, this is this is the ultimate family jewel, right? This is the thing that allows every single cell in my body every single tissue to function the the brains of, you know, to a brain, the liver to be liver, the the pancreas, the heart, you name it, you would think that this would be protected against damage by, you know, the homeo- static forces that that we have operating in just to clarify what that means. That means that the ability of the body to maintain, you know, things in a regular state, like keeping our body temperature at ninety eight point six. You know, when we go up too high, we have ways to cool down when we're too low, we've ways to heat up. So you'd think that your energy would be protected. But it turns out that are NA NASD and are any ph is under stress in a number of conditions like alcohol. So when we drink alcohol, our n. d. pluses converted to an h. and then the food that we eat, where we wanted to be converged energy can be converted to an alcoholic, fatty liver. That would be a case of excess alcohol though, right? In the case of excess alcohol, right. That's is that, is that why that that a lot of like anti-aging docs will tell you that the worst possible thing you can do fear, stem cells drink too much alcohol. It's not only your stem cells. The metabolism happens in hip Hata site. So in, you know, the the functioning cells of the liver. Themselves, but then then the liver becomes infiltrated by macrophages and all sorts of inflammatory cells. And you know it just we generate acid ala hide, which is toxic. And you know, the biochemistry of alcohol is actually really well known, and it's really well known to depend on n. a. d. in particular Reebok's form and so are are, are you know, vitality becomes stressed when we are metabolising too much alcohol. That's actually something that really, you know, it requires some thinking about because most people think, oh, I drink alcohol in order to de-stress. But if you talk to a biochemist, a biochemist will tell you, oh alcohol, is it self a metabolic stress? And it's metabolic stress precisely because of what it does to our any diesel system. So this NA system in addition to getting damaged by, let's say, alcohol or excess stress, or you know having to having to engage in excessive Reebok's reactions from just pushing food through and making ATP is the damage like structural? Is that how the damage would occur or is the damage simply you get depleted of in a d. because so much gets converted into any d. h. so that there's there's enough reducing agents to donate electrons. Good question, and I want to make sure I tell you the six other major conditions that that attack in a d so so let's run through them. And then we'll talk about the consequences of what happens when you're NASD or any BPH is under attack. So number one is alcohol and I, I always bring that went up. I, I bring alcohol up first because we know the most about it and I bring aging a ba- up last. Because we know the least about it. But alcohols number one number two is what I call over nutrition. So we, we set up an experiment in which we basically over fed mice, and we made them fat with a high fat diet, and we push some of them over the edge into type two diabetes. And we wanted to see what effect that was going to have on their liver and a decent them..