CYP, Copd, Lavera discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals


Alright. So finishing <Speech_Male> up on <Speech_Male> drug <Speech_Male> interactions <Speech_Male> I would say <Speech_Male> there's <Speech_Male> not a ton <Speech_Male> of clinically significant <Speech_Male> drug interactions <Speech_Male> with valley <Speech_Male> sick liver. So that's <Speech_Male> definitely <Speech_Male> a nice thing there. <Speech_Male> <hes> <Speech_Male> I think about additive <Speech_Male> adverse effects. <Speech_Male> So liver toxicity, <Speech_Male> I mentioned <Speech_Male> there. <Speech_Male> <hes> also <Speech_Male> <hes> <Speech_Male> Mild <Speech_Male> Cyp, one, <Silence> a two in addition <Speech_Male> can <Speech_Male> happen from <Speech_Male> valley <Speech_Male> sick leave here, <Speech_Male> and if you remember <Speech_Male> some of those agents <Speech_Male> that <Speech_Male> are <Speech_Male> metabolized <Speech_Male> by Cyp. Twenty. Two <Speech_Male> <Speech_Male> Probably, the two <Speech_Male> most common <Speech_Male> examples <Speech_Male> <hes> I've seen <Speech_Male> used in clinical practice <Speech_Male> <hes> <Speech_Male> Tazawa an <Speech_Male> older skeletal. <Silence> Muscle relaxant. <Speech_Male> <Speech_Male> <hes> and then <Speech_Male> clause, which <Speech_Male> is an. <Speech_Male> ANTIPSYCHOTIC <Speech_Male> <hes> definitely <Speech_Male> notable for <Speech_Male> a grain, <Speech_Male> toast us <Speech_Male> and and other <Speech_Male> <hes> boxed warnings <Speech_Male> as well. So <Speech_Male> those those two <Speech_Male> <hes> <Speech_Male> I would say it's <Speech_Male> probably not <Speech_Male> strong <Speech_Male> strong clinically <Speech_Male> significance <Speech_Male> <Speech_Male> but <Speech_Male> it is there <Speech_Male> in concentrations <Speech_Male> of <Speech_Male> Dean <Silence> or Ping. <Speech_Male> <Speech_Male> Could go <SpeakerChange> up <Speech_Male> <hes> <Speech_Male> CYP one, a two <Speech_Male> also the offline <Speech_Male> I did want <Speech_Male> to mention. I. <Speech_Male> It's been a <Speech_Male> really really <Speech_Male> long time since I've <Speech_Male> seen <Speech_Male> The <Speech_Male> offline because there is <Speech_Male> <hes> so <Speech_Male> many drug interactions <Speech_Male> and adverse <Speech_Male> effects and risk for <Speech_Male> tax city <Speech_Male> and we we've <Speech_Male> got a lot <hes> <Speech_Male> safer medication <Speech_Male> options <Speech_Male> in <hes> <Speech_Male> COPD and <Speech_Male> other respiratory <Speech_Male> disorders <Speech_Male> that we would use the <Speech_Male> offline for. So <Speech_Male> <hes> <Speech_Male> again, it is broken <Speech_Male> down by Cyp one a <Speech_Male> two but. <Speech_Male> The likelihood <Speech_Male> that you see a patient on <Speech_Male> that medication is <Silence> is pretty pretty low. <Speech_Male> <Speech_Male> And then the last <Speech_Male> thing I did want <Speech_Male> to mention with <Speech_Male> Valley <Speech_Male> Cycler <Speech_Male> is <Speech_Male> you've got to think about live <Speech_Male> vaccines <Speech_Male> particularly <Speech_Male> <hes> live <Speech_Male> vaccines that <Speech_Male> are viruses. <Speech_Male> So <Speech_Male> the Verret Selah <Speech_Male> vaccine, for example, <Speech_Male> if you've got a patient <Speech_Male> taking <Speech_Male> valley <Silence> sick Lavera, <Speech_Male> it could <Speech_Male> interfere <Speech_Male> with <Speech_Male> <hes> <Speech_Male> the <Speech_Male> response <Speech_Male> to that vaccine. <Speech_Male> You may not get quite <Speech_Male> as robust <Speech_Male> response. <Speech_Male> So definitely <Speech_Male> <Speech_Male> important. I <Speech_Male> think to <Speech_Male> remember that. <Speech_Male> Doesn't <Speech_Male> happen credibly <Speech_Male> often at <Speech_Male> least in <Speech_Male> my practice <Speech_Male> that you <Speech_Male> run into that <Speech_Male> <hes> <Speech_Male> but think about <Speech_Male> <hes> those live <Speech_Male> scenes <Speech_Male> particularly <Speech_Male> <hes> with Vera, <Speech_Male> Selah because <Speech_Male> valley <Speech_Male> sick Lavar can <Speech_Male> be used in that <Speech_Male> setting to help <Speech_Male> <hes> blunt <Speech_Male> that type <Speech_Male> of infection. So <Speech_Male> as you can imagine <Speech_Male> it also <Speech_Male> might blunt <Speech_Male> the effects <Speech_Male> <hes> from a live vaccine <Speech_Male> that requires <Speech_Male> replication <Speech_Male> and all that sorta <Speech_Male> stuff. <Speech_Male> I <Speech_Male> think that's going to wrap <Speech_Male> it up for today <Speech_Male> if you enjoyed <Silence> the podcast. <Speech_Male> <Speech_Male> Do as huge favor <Speech_Male> helpless grow the audience <Speech_Male> <Speech_Male> You know share us, <Speech_Male> you know colleagues, <Speech_Male> friends, <Speech_Male> email list serves <Speech_Male> you're on <hes> <Speech_Male> definitely <Speech_Male> <hes> shares <Speech_Male> as a resource <Speech_Male> trusted resource <Speech_Male> to <Speech_Male> <hes> provide <Speech_Male> medication <Speech_Male> education basically. <Speech_Male> Then in <Speech_Male> addition to that <Speech_Male> if you've got, you <Speech_Male> know a quick second <Speech_Male> leave us <Speech_Male> a rating and review <Speech_Male> on on itunes <Speech_Male> or whatever platform <Speech_Male> you're listening on <Speech_Male> that. Also <Speech_Male> <hes> helps us <Speech_Male> get more exposure <Speech_Male> and grow the audience. <Silence> It's And of course, you can <Speech_Male> <hes> get updates <Speech_Male> <hes> to <Speech_Male> when we have new podcasts <Speech_Male> as well as <Speech_Male> a new information <Speech_Male> educational <Speech_Male> materials <Speech_Male> We <Speech_Male> also keep <Speech_Male> you in the loop on that <Speech_Male> at real life pharmacology <Speech_Male> dot com. <Speech_Male> <Speech_Male> Sign up and get that <Speech_Male> <hes> top <Speech_Male> two, hundred study <Speech_Male> guide. <Speech_Male> So I'm going to sign off <Speech_Male> today. Thank you so <Speech_Male> much for listening and I hope you have a great rest of your day.

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