Alzheimer's Disease, Coleen Dha, Doctor Rhonda Patrick discussed on The Kevin Rose Show


Everybody kept rose here. Welcome back to another episode of the Kevin Rose Show happy twenty twenty a brand new year and so I'm really excited to have doctor Rhonda Patrick on the show because what better way to address in health and longevity in January. It's surely a topic that is on a lot of our minds. I for one. I'm going to try try. Mostly mostly Pasqua -Tarian Diet for this first month and get my blood work checked and see what it does to some of my numbers I'm also going to be cutting out drinking drinking for the most part because I have a plan to Japan at the end of the month I will be drinking in. Japan will be having Saturday and good Japanese beer but the first few weeks they will not have any any drinks and get by blood tested before all of that anyway. Doctor Rhonda Patrick is one of my favorite scientists. She goes in reads leads. All the published studies around health and longevity and really takes that information out of there that is too technical for the average person to understand and then translates slates it into things that we can incorporate into our everyday lives. This is the best way to get your health advice. People like doctors are always always four five ten years behind except for some Dr Peter but but the average doctor is is many years behind what the science is actually telling us to do. So if you want to know the latest and greatest it's best to go to scientists and thankfully do to podcast. Ron has a fantastic podcast and also a great website called She has been able to give us that direct link to scientists and so she interviews a bunch of great scientists and really help help us make better decisions earlier on so for example in this episode. We talk about mega threes. Why they're not all created equally and there's various this different forms of Omega Three? We talk about which ones that she takes. How much she actually takes personally? Lots of great information there because not only is she Understanding understanding the science to relate to us but also has published her own science around mega threes. And she's done a bunch of research in regards to make it through his impact on dimension in Alzheimer's so great to half talking about that we also talk about metformin which is very hot drug right now hot. I don't know if he can call a drug hot. But it's a very very popular drug at least in Silicon Valley For people take into extend life and some of the potential pitfalls that it has we also talk about a compound called so for vein gene which is found in Broccoli. She talked about at length on her own podcast about sulfurophane but there is some new data out there that we cover we also talk talk about a new brand of sulfur fame that she has imported that she takes so a lot of interesting stuff. There we cover sauna usage. Some new studies have come out there so a lot of really new things to chat about in this was a great episode. I really enjoyed it and I know that you will too so happy. Twenty twenty cheers to you really hoping that all of us happy and healthy this year Introduced some new healthy habits into your life and Hopefully subscribe to all of Rhonda Duffy as you'll hear her talk about later in the episode when she talks about all the new things that she's building for her website as well so I hope you enjoyed the show this is doctor. Rhonda Patrick Doc Rhonda. Thanks so much for coming back on the show you were actually my very first guest in now. I look back. And I'm almost like forty plus episodes deep so so thank you you for returning a totally. Yeah I totally remember that. For the first episode recorded a few years ago I was living in New York. I didn't have any babies like you didn't have any babies excite change definitely. Things have changed a lot. Becoming a parent is like the the definitely a huge change in the life. Yeah absolutely fluently. I'm just now returning getting enough sleep against the things are things are looking up especially for for Doria's well one of the things I wanted to cover. That has changed since as we last talked as you had really gone deep and published a paper around the phospholipid form of Omega threes than its benefits. I was wondering if you could bring us up to speed on that And what your current thinking is on Omega three supplementation so when it comes to talking about phospholipid. Dha When it comes to DHA General D H as one of the Omega threes? It's predominantly found in marine sources. Really what I care about. Is You know getting it to the brain. That's like my number one interest and the only type of Dha that crosses the the blood brain barrier is Dha that is bound to albumin which is a protein found in your bloodstream? Transports a variety of goodies. In addition to Dha to other tissues including the brain rain but there are two forms of Dha that are bound to albumin and these different forms are transported by different mechanisms so the first is Dha that that is not as terrified. It's not bound to anything other than albumen. So it's in a free fatty acid form and I often refer to that as Dha a free it's free it's not bound to anything. Aside from albumin. It gets transported across the blood brain barrier via this mechanism. That's passive diffusion. and which just means it's you know passably crossing the blood brain barrier and the blood brain barrier. There's a variety of things that you know. Make it up but but one of the things that's important in this discussion. Is that endothelial cells. Line the blood brain barrier and they're the endothelial cells are attached to each other by lied tight junctions so this passive diffusion mechanism. Where'd free? Dha gets across the brain depends on the integrity of the blood brain barrier so so Unfortunately as we age the blood brain barrier becomes compromised and this is even more of an issue and people that have an April four L. E. L. April four is just a gene and A Lil just means one copy of the gene. You have two copies of every gene one from your mom one from Your Dad's we have up to a liles of every gene and just bring people to speed if you have one copy of this gene. Your how much more likely to get Alzheimer's Disease People that have one copy of the April. Four ELEO are about to twofold more likely to get Alzheimer's disease and people that have no copies of it people that have two copies of it. It's not very common so about twenty five percent around. The population has at least one copy of it to copies much much less common. I don't know the percentage off the top of my head but you can figure the math out if you know. Twenty five percent has one copy what you know. Two copies would be but that increases the risk for Alzheimer's disease from anywhere between ten to fifteen fold in. What percentage of the population that is diagnosed? Those with Alzheimer's disease has at least one copy anywhere between sixty five to eighty five percent. Wow Yeah so this is a pretty big indicator then it is and we could spend hours talking about the reasons why that is and I do talk a lot about that in my paper that he published last October in Facet Journal but but basically to get back to the whole. Dha Part of the story. I mentioned that there's two ways it can be transported brain. This one form that's free you know not bound to anything other than albumin. It goes through passive diffusion however April before actually disrupts that because it does compromise the blood brain barrier and that even gets worse with age things like traumatic matic brain injury also compromised barrier. The good news is there is another form of Dha that is bound to albumin. It's a form that is a specific type of fossil so lipid form called Leisa foster title Coleen Dha or Dha Lice OPEC as. I like to call it for short. And that's also transported across the blood brain barrier through an entirely different mechanism uses a transporter called. MFS D to a and basically when this phospholipid form of Dha binds to the transporter the transporter flips it across the outer membrane into the inner membrane of the blood brain barrier potentially bypasses any defects for example apple in tight junctions. NFL's just mentioning. which by the way April before does disrupt tight junctions in lining the blood brain barrier? So I sort of argue in my latest publication that this specific Dha Lice O.. P. C. Form of Dha may be a nice way to bypass that defect that April before it causes or even just normal brain aging causes where you can get Dha into the brain is. Does your hypothesis here. That lack of this. Dha is a cause potential cause of of dementia yet specifically making people with April four more susceptible to it so Dha plays a lot of important roles in the brain. It plays a role in preventing and ameliorating a couple of the hallmarks marks associated with Alzheimer's Disease Tangles and Amyloid Beta plaques and that's been shown in clinical studies it's been shown that Dha supplementation. Can Dan lower the amyloid burden. And also tangle pathology in people have them so specifically people with Alzheimer's disease and it also can improve cognitive function The other thing that. Dha does it's really important for transporting glucose across the blood brain barrier and this is a really really major hallmark of Alzheimer's Disease Not Getting Glucose into the brain. Basically that is actually something that can be observed before any other clinical features of Alzheimer's disease and it's specifically specifically found early people with April four so DHA's important for increasing levels of the transporters that transport glucose across the blood brain barrier the glucose transporters. So I I always thought that you know people for a while. We're calling dementia or Alzheimer's disease like potentially type three diabetes ladies. I'm sure you've heard it called that before I always thought an increase. Too Much Glucose in the body would be a bad thing but here you're saying the brain getting a lack of glucose is the bad thing what I'm saying here. Yeah is that getting not having glucose in the brain can be a bad thing. But that's separate from obviously from like district. Blood Blood Glucose I levels and insulin insensitivity lick. Those things are all hallmarks of aging and cause multiple multiple problems for sure. It's kind of a different thing that I'm talking about here So like brain glucose levels are important for preventing a lot of the the hallmarks associated with Alzheimer's disease. And this has to do with with a lot of like very specific molecular mechanisms having to do with like forming cow tangles and stuff like that so not being able to get glucose into the brain can play a causal roll out hammers disease. And perhaps that is also linked to this type three diabetes that you're referring to that would be you know a completely separate but sort of a parallel mechanism Gotcha. Dha I think it could play a role in addition rice or Dha is important for getting glucose in the brain but also some new research does indicate that you know insulin. Insensitivity can reduce glucose getting into the brain as well so those things could even possibly center. Dr Dr who knows I mean it'd be nice to see data on that but in terms of getting the and the brain and like the question you kind of asked at the beginning. I'm and I'm sure people are wondering is like what what are the dietary sources of these different types of Dha the free Dha versus Lice OPEC Dha the one that's phospholipid form..

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