Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19

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As a researcher Joe Garcia Applied Functional Genomics to understanding genes that contribute to inflammatory disorders such as acute respiratory distress syndrome or arts as founder and CEO of the Biotech Company. Akwa Lung Therapeutics. He's working to advanced therapies to hit these novel targets to treat unchecked inflammation with the company's lead experimental therapeutic candidate targeting arts. We spoke to Garcia about the company's arts. Therapy how it works. And why it's time we focus given the cove nineteen pandemic Joe. Thanks for joining us. To be here thing we're going to talk about Aqua Lung Therapeutics Acute Respiratory Distress Syndrome or arts and your efforts to develop a treatment for this condition. Let's start with ours though. What is it and how big a health challenge? Does it represent about half a million people. Every year get air F- Acute Respiratory Distress Syndrome in the United States alone. And you know close to two million. Maybe globally so it's it's not a uncommon Disorder But it is a extremely challenging to treat disorder because mortality of this. Anyone that had gets a yard is Thirty to forty percents In the US and it's probably higher Outside the US what makes it so challenging to treat? Well it's It's sort of the ultimate in inch in the stress to To a human being in that They have multiple attacks on a variety of Oregon starting with the lung though the the most common causes of ARD s are sepsis which is infection in the bloodstream and trauma and Smoking elation will do it and that Curiel and viral pneumonias and so as a result the starts off with inflammation in the lung from those particular Causes the inflammation becomes waves waves of amplify inflammation that starts to affect other organs. Like your kidneys and heart and ultimately patients with AIDS wind up. They don't survive. They die from that multi organ failure and that he's organs weren't able to sustain the inflammatory injury we've heard a lot about the respiratory challenges that can occur to people infected with the covid nineteen virus are the ones who end up on respirators suffering from arts and what role does arts play in the mortality of patients with Covid nineteen arches probably the primary cause of death in most of the cove in nineteen patients. At least that's what the the reports from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards has a lot of similarities to garden variety area but it also has some unique changes that that may not be typical. Air S. as well and The ventilator Think this is an important part of the story. That patients with With Kobe nineteen viral infection or other causes of Respiratory distress like I mentioned substance or bacterial pneumonia trauma and you have Increasing respiratory distress your lungs. Start to fill with Lewis and the work of breathing when your lungs are. Our full of fluid is very very rate. So these patients generally run out of Energy the fatigue and they need then later to help with their respiration and so the the the the irony of of this is that the ventilator while saving your life because your new patients for an out of energy agreed on their own then later also the major cause for information as well. That's been known for now sometime and so strategies to address a yes whether it's cove nineteen induced or otherwise need to take into account the fact that then later contributes to that inflammatory burden patients with they as an academic. You've done functional

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