Eleven, Nineteen Percent, Seventeen discussed on The Blog of Author Tim Ferriss
In terms of like nerdy out on all of the molecules it can potentially impact longevity and rapamycin was in many ways the poster child for the it p. program because first of all it's hard to get anything to live longer second of all when they were making the formulation for the rapamycin to feed the mice and these were very special mice. These were not your typical crappy lab mice that have no bearing whatsoever to real animals. These are very special type of mice. That are much more akin to real animals and that's very important distinction between what happens in ninety nine percent of miles research which is almost in applicable to humans. And it's why so many drugs that get tested in these b six mice and things like that show some marker of success and they become wild failures beyond the mice. But this was different. They had trouble getting the formulation to work and by the time they finally did the mice were like twenty months old. Which means they're almost at the end of their life. They're like seventy year old sixty five year old mice and they contemplated just scrapping the experiment but they were like screw it. Let's just run it late. So they started feeding the treatment group with rapamycin and the placebo group. Get to continue eating their regular chow. Because it was oral administration yes rapamycin was mixed into their chow. And lo and behold the rapamycin group despite initiating treatment so late in life had a staggering improvement in lifespan. There's been so many it. Ps that have replicated this. I don't wanna misquoted. But something to the effect like a seventeen or nineteen percent improvement in the males or females and eleven to twelve percent in the males and remember the atp used the very rigorous way of assessing this. Which is they're taking a look at total life not just remaining life. It's an even higher bar to clear. How much lifespan. Along gatien happens of course went and repeated. The study administering the dose when they were younger and saw an even greater response. This has been repeated over and over and over again and to my knowledge there is not a single animal. Study that has tested this hypothesis. That has not found on as a result of that's wild which again is very unusual Since it's just replicated over and over and over with replicated non stop what is also interesting is when looking at other markers other interesting things such as vision and hearing and other markers of health span. We continue to see improvements in these things for animals as well as i think we even spoke about before the guy named matt cable line who just interviewed for a second time for the podcast has been studying this in companion dogs and looking at heart function because as you know basically two things kill companion dogs primarily heart failure and cancer and.