Listen: Retrograde Amnesia, Caselli, Ataf Adji discussed on The Peter Attia Drive
"So that's a grossly disproportionate amount of energy and the second, by the way would be the kidney. Which by the way is the second organ. We tend to see great schemic when we see Hypo perfusion clinically. We see kids. Damage and my cardio damage. Yes. So the more energy demanding the organs bigger the problem. And then the second issue at the brain is this seemingly overreliance on data phosphorylation without an anaerobic escape route. Yes, you are right on target. And these what makes it so Bullman -able. And these y we see these changes more has kinda deficit before all these shoes are really damage or the bring itself, but as you continue with this process. We just talk about IPE down regulation outside the grandma Auxerre reached certain level Sodom sees gonna start releasing the there is the spending the change goes out and sell star dying soul eighties. The direction of Caselli the is completely different from the amulet ideas. Bam, you know, comes there because of the gene that is normal. And then he creating these gas gays are leading to these changes. No will we have. Eats the sprawl with supply of oxygen the happened to the brain and his his high energetic demand, and they could be due to the circulation or due to a cardiac effect on the circulation, but unfortunately, the Basque ler high built his dementia is not exclusionary because you have talks ick insults that affect they might country that will for all these are logic purposes will do something similar to these cardiovascular insults. In other words, they going to lead also to down regulations remarks days, and you're in availa do use oxygen to generate energy. So that's why I have us that Aintree point into the system because it is completely consistent with vascular hypotheses dementia. But it also bro is room for all their insults. The brain are going to be. Reflected the level. And he's only when they're reflected the level, then they because of these energetic demand bullet realty that you alluded to that. Then this is going to lead to a cognitive why Canada problem and not something else. Because when we are engage in these functions that is playing we these functions are not limited to one region of the brain there relied on interaction between different regions. So when you're reading song saying that information goes to racial system. But then if you're gonna engage learning having the with that that would engage oh the system, so they memory functions are more distributed. So when you have a more distributed all again salt they're going to be affected each just like people know somebody may get a blow to the head. And they know this all in they may have retrograde amnesia. They may not remember what happen even remember who they are. And you may not see any significant level of structural or functional damage, but you affected the way this is simply putting that acting more global way. So this is one of the reasons we detect this primarily as more. Reprogram initially lay. Their owning becomes a narrow degenerative disorder. When when cells longer were without these might gone. We have any insight into how much might offer g or esophageal Ataf Adji is going on in the later stages of Alzheimer's disease. In other words, is it possible that so much of this damage is now due to defective cleaning up of the mitochondria because the more these might economy are damaged the more might Conrail DNA's getting released. The mighty Conrail DNA itself is actually looks bacterial. So it elicits immune response, this probably accelerates the process. It would seem that anything that would increase my tough achier tough Aji would at least be able to curb the progression of the feed forward loop on this damage going and exceleron within that yet make sense. I agree however do late if you already compromised. Cini folktales the energy is too late at that point soul. My fog was on the fog of Jag dilatory. And all the people is how can we intervening, for example, one ways in the risk factors, thou with the Cadillac square compromise thri in the ring with the risk factors. Besides blood pressure. What do you view as the most important risk factors."