Listen: Autoimmune Disease, Remission, FLU discussed on The Bio Report
"Dexterity and the company efforts to bring the benefits of precision medicine to people with autoimmune diseases. If If you you think of. think of the diseases dexterity is focused on MS lupus rheumatoid arthritis. A common element of these conditions. That patients will go through periods of remission separated by flares for listeners, not familiar with flares. Can you explain what they are? Now. The short version is temporary worsening of disease condition, you know, autoimmune diseases different from a lot of other ones in that. It goes curious of what seems like remission, but will then go through a period of intensity where it really picks up in for not really sure why from a biological point of view what what's happening during these flares. It's a little different everybody. But on one level your body for whatever reason has decided that it is mounting, a more intense immune reaction against something in your system. It's RA Julie joint or the liquid in the joint if it's something like this. It can be anywhere throughout your body from a patient point of view what happens to someone during their health change. How were they treated? It can vary greatly in some cases, it can be just. More discomfort have difficulty movement for other individuals that can be really the ability beyond able to get out of bed. That'd be very similar to if they were had the flu very hard and very fatigued. We've seen great advances in precision medicine the ability to develop more targeted interventions. Detectives eases earlier stages before they can be tougher to treat and do greater damage, but I you that most of the efforts today focused on cancer in which you're also working in are there things like autoimmune disease just more complicated or not as well. Understood. Or is it just not as economically attractive a market? Well, it's a little several different things. There are some commonalities between cancer and autoimmune disease. An answer particularly eleven relevant nowadays is immune therapies for treating cancer come on board. But there's also quite some differences. You know, in the US, we have a very strong, focus on cancer, the cancer moonshot, and such and autoimmune diseases of you know, you tend to have to look at different types of marker. And it's a different way of treating them of versus cancer Kanter tended to be a single episode that you're really focused on trying to figure out what's going wrong. Very often the precision medicine is based upon looking at the tumor itself and mechanism like a mutation that has led to a change in autoimmune disease, you need to look at a different molecule than DNA. You're looking at. Arne his DNA's dynamic cousin, and you are looking to see what is changing in terms of how your body is reacting and it is this evaluation of immune response that is key to apply precision medicine. What's the potential to detect flares before they become full blown and the benefit of doing? So be. Well, I mean first thing is understand the magnitude of auto immune disease. Whether people realize authors, really autumn, you Napa democ in the US. And I h estimates had there's at least twenty three million individuals living with an autoimmune disease the auto immune related diseases sociation estimates that number closer to fifty. There's more than eighty different conditions, but some of the most prevalent tend to be are a lupus MS and the difference between them is what part of your body. Your immune system has decided is you know, is foreign that it needs to attack. If it was a virus or germ. If you could for these people had leaving normal life is very difficult. Imagine if you were always feeling like you were flight of fighting the flu, and they're very often is very little information to give them, you know, to predict whether or not there's going to be a flare up in their disease activity. If we can learn how to monitor those patients effectively from home to spot of flare before the change happens such that you can bring them in to increase their treatment. Or, you know, the even greater. Moonshot would be to say can we read not only your home monitoring of."