Oxford Penicillin, Penicillin, Albert Alexander discussed on Stuff To Blow Your Mind
Twelfth Nineteen, forty, one, a forty three year, old policeman Albert Alexander became the first recipient of the Oxford Penicillin he'd scratched the side of his mouth while pruning roses, and developed a life threatening infection with huge abscesses affecting. Affecting his is facing lungs, penicillin was injected and within days he made a remarkable recovery while, but unfortunately despite this recovery, which lasted for a few days they ran out of the drug and Alexander, eventually got worse again, and he died and I was reading that they were so desperate to cure him that after Alexander urinated while on his antibiotic course, they would. Would collect the urine and try to extract the penicillin. He excreted again so that it could be re administered to him. and I should mention also that the the process that the Oxford team relied on to extract and purify the penicillin. The mold juice was led by another important biochemist, a guy named Norman Heatley but this case of Albert Alexander shows. Shows an obvious early problem they had which was the problem of scale. They simply lacked the ability to make penicillin scale it that would be needed to even one person. Let alone. The whole world the strain of mold that they were using didn't make enough of it, and this led to the search for other species of the same fungal genus concilium. concilium, which would maybe they thought produce higher concentrations of the Penicillin Phil Trait, and I was reading an interesting article by the University of Michigan Physician and medical historian Howard Markel. That tells a really interesting story I'd never heard about this The so the story goes like this. Apparently, one of the assistance at the Oxford lab showed up for work one day. Day In nineteen, forty, one with a cantaloupe that she'd bought at the market because it was covered in a weird looking golden mold, which is great, because this would be the one case where somebody is picking over the fresh produce to like find the moldy one but the mold on this cantaloupe turned out to be a strain of penicillin called penicillin. Chris. Chris O. GM with Markle says naturally produced at least about two hundred times as much penicillin as the original strain that they've been studying and then later, markel writes the same strain was subjected to mutagenic processes in the lab, so like bombarding it with x rays and stuff to produce a mutated strain that would make up to a thousand times as much. Much insulin as the old school fleming mold so by nineteen forty one penicillin is on its way to becoming a viable medicine. All right on that note. We're GONNA take a quick break. When we come back, we're going to look at the impact of penicillin and we're going to look at it.