Gastric Ulcers, Gasser, Gastritis discussed on This Podcast Will Kill You
And remember those two guys, who I just mentioned that the first declared this link between gastric ulcers and bacterial infections. So even the mostly everyone else had dropped that concept they were still convinced and so by eighteen eighty eight a ton of progress had been made and identifying different bacterial species, and the diseases, they caused just in general so. These guys are picking candidate microbes such as staff, Oreos and strep to see if they caused alters when injected into the stomach of various lab animals, and no surprise. They did. But that was sort of a problem, right? Because if all of these different species could cause gastric ulcers, how do you distinguish between the types of ulcers and between whether this bacteria causes an ulcer or whether they're just general ulcer, causing bacteria right after the tool was able to induce ulcers in his Guinea, pigs? Other people started to get interested and found that a whole bunch of bacterial species could lead to Gasser duodenal ulcers, but there is still so much to be figured out and gastric ulcers were tricky business. Because like I said, you can get alteration with many different diseases. And you could induce it with many different bacterial species. So how do you pinpoint exactly which species causes ulcers for sure rather than just these opportunities? Mystic. Infections. Right. Or which, which does it in real life versus just if you injected in the lab? Exactly. Yeah. And so really what became more popular in terms of why gastritis and peptic, ulcers exist, was that excess acid that, that could be triggered by the ingestion of foods or drinks high in acidity stress etcetera. And this explanation resolved a few things that were maybe more difficult to align with the bacteria hypothesis, so often people who experienced ulcers didn't have symptoms all of the time the head flare ups, and then they would resolve after cutting back on certain foods or taking lots of anti acids. And so, during this time it was basically conventional wisdom that bacteria couldn't survive in the high acidity environment of the stomach. So if back Tiriac were found in the lesions they were probably from ingested food more. The stomach was weakened enough to allow for these opportunistic, invaders. So it was like they were secondary the where the primary rather. Yeah. Interesting. Yeah. And it wasn't so much that people weren't finding H pylori and stomach tissue. Cameo b-actor like or curved, rod bacteria had been reported as part of the gastric flora for decades. But no one had had much luck in investigating them in the nineteen fifties..